Treatment of Youth Alcohol Abuse and Suicidality

青少年酗酒和自杀的治疗

• 批准号: 6733185
• 负责人: CHRISTIANNE L. ESPOSITO-SMYTHERS
• 金额: $ 35.47万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6733185
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; alcoholism /alcohol abuse therapy; behavioral /social science research tag; clinical research; clinical trial phase I; cognitive behavior therapy; comorbidity; coping; group therapy; human subject; human therapy evaluation; marijuana abuse; patient oriented research; suicide

DESCRIPTION (provided by applicant): This application is being submitted in response to NIAAA PA-02-067 "Treatment of Alcohol Abuse/Dependent Patients With Psychiatric Comorbidity". Adolescent alcohol abuse/dependence is a serious public health problem associated with life threatening outcomes. Among adolescents in alcohol/substance treatment, up to 67% exhibit suicidal ideation and 30% suicidal behavior. Integrated interventions that incorporate treatment of these co-occurring problems have not been tested with adolescents. The primary purpose of this proposal is to conduct a randomized Stage I trial to evaluate a manualized cognitive behavioral treatment protocol for adolescents with alcohol use disorder and co-occurring suicidality. Our long term objective is to yield a more effective and feasible outpatient treatment approach for adolescents with these co-occurring conditions. There are three primary aims in this project: 1) pilot and refine the manualized cognitive behavioral treatment protocol for adolescents with alcohol use disorders and co-occurring suicidality; 2) test this intervention in a small randomized trial to calculate an effect size for a future Stage II clinical trial; and 3) demonstrate feasibility and acceptability of this intervention relative to non-integrated treatment. To accomplish these aims, a two step sequence of treatment development is proposed. In Phase I therapists will be trained, cases will be piloted, and manual revisions will be made. Phase II will include a small randomized trial. Adolescents discharged from a psychiatric inpatient unit will be randomly assigned to the integrated cognitive behavioral treatment or the non-integrated treatment for their outpatient care, both provided by project staff. The integrated treatment will include 20 sessions of cognitive behavioral therapy, provided by one therapist, which integrates treatment of alcohol use and suicidality. The non-integrated treatment will include 12 sessions of cognitive behavioral therapy targeting suicidality and 8 sessions of psycho-educational group therapy targeting alcohol use, each provided by different therapists. Outcome will be assessed at the end of treatment and 6 months post-treatment. The proposed treatment is designed to address objectives18-10 and 18-2 of Healthy People 2010 to "increase the proportion of persons with co-occurring substance abuse and mental disorders who receive treatment of both disorders" and "reduce the rate of suicide attempts by adolescents".

描述（由申请人提供）：该申请是针对NIAAA PA-02-067提交的，“治疗酒精滥用/依赖于精神病合并症的患者”。青少年酒精滥用/依赖是与威胁生命的结果相关的严重公共卫生问题。在酒精/物质治疗中的青少年中，高达67％的人表现出自杀念头和30％的自杀行为。尚未与青少年一起测试结合这些同时发生问题的综合干预措施。该提案的主要目的是进行一项随机的I期试验，以评估患有酒精使用障碍和同时发生自杀性的青少年手动认知行为治疗方案。我们的长期目标是为患有这些同时发生条件的青少年产生更有效和可行的门诊治疗方法。该项目有三个主要目的：1）针对患有酒精使用障碍和同时发生自杀性的青少年的手动认知行为治疗方案进行试验和完善手动认知行为治疗方案； 2）在一项小型随机试验中测试此干预措施，以计算未来II期临床试验的效应大小； 3）表现出相对于非集成治疗的这种干预措施的可行性和可接受性。为了实现这些目标，提出了两步的治疗开发顺序。在第一阶段的治疗师将接受培训，将进行案件，并进行手动修订。第二阶段将包括一项小型随机试验。从精神科住院单位出院的青少年将随机分配给综合的认知行为治疗或项目人员提供的门诊护理的非集成治疗。综合治疗将包括一位治疗师提供的20次认知行为疗法，这整合了酒精使用和自杀性的治疗方法。非集成治疗将包括针对自杀性的认知行为疗法的12次，以及针对靶向酒精饮酒的精神教育群体治疗的8次，每一次疗法由不同的治疗师提供。结果将在治疗结束时和治疗后6个月进行评估。拟议的治疗旨在解决2010年健康人的目标18-10和18-2，以“增加患有滥用药物的药物滥用和精神障碍的人的比例”，并“减少青少年自杀企图的速度”。