Craving & EtOH Intake in Alcoholics: a Test of 2 Models

渴望

• 批准号: 6807546
• 负责人: Dena Davidson
• 金额: $ 22.58万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6807546
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; behavior prediction; behavioral /social science research tag; clinical research; craving; cues; emotions; human subject; motivation; psychological models; substance abuse related behavior

DESCRIPTION (provided by applicant): Craving is arguably the most contentious construct in addiction research. On the one hand are the testimonials of alcoholics that cravings dominate their thoughts and weaken their resolve to stay sober. On the other hand, research finds that craving is neither necessary nor sufficient to explain drinking. In 1996, the NIAAA brought together addiction experts to determine why craving is not a reliable predictor of drinking. One of the gaps in the knowledge base identified by this group was that craving has not been adequately conceptualized and studied in humans. Lack of such research is an important problem because it impedes the understanding of the nature, course, behavioral sequelae, and regulatory function of craving on alcohol consumption. The long-term goal of my research is to better understand the phenomenon of craving and its relation to drinking and relapse. The objective of this application is to examine 2 influential models of craving, the Cognitive Processing Model of Craving and Drug Use, and the Two-Affect Model of Urges and Drug Motivation, which yield different predictions regarding the association between craving and drinking. The central hypothesis of the proposed research is that the circumstances under which craving is likely to predict drinking will only be elucidated through theory-driven research and the use of paradigms that can manipulate factors known to elicit drinking, and simultaneously measure craving and drinking behavior. Three studies are proposed to investigate factors known to elicit drinking in alcoholics by using an innovative modification of conventional cue-reactivity methodology-the cue-availability paradigm. Study I will examine the effects of alcohol priming and alcohol availability on craving, affect, alcohol seeking, and drinking behavior in non treatment-seeking alcoholics. Study 2 will examine the effects of negative mood induction and alcohol availability on craving, affect, alcohol seeking, and drinking behavior in non treatment-seeking alcoholics. Study 3 will replicate and add to the findings from Study 2 by providing a test of convergent validity on drinking behaviors measured by the cue-availability paradigm to similar measures assessed by a validated taste-rating task. The effects of participating in these laboratory alcohol administration studies on subsequent ad libitum drinking will be measured as a secondary aim. The proposed research is innovative because it uses a paradigm that has the flexibility to manipulate factors known to affect alcohol seeking and drinking behaviors, simultaneously measures craving and affect, and tests two models of craving. We expect that this research will provide important new information regarding factors that moderate craving, and the association between craving and drinking in the population of interest-alcoholics. The major impact of this research will be to address a gap in the knowledge base regarding the conceptualization of craving in humans, which in turn will advance the field and inform patient care.

描述（由申请人提供）：渴望可以说是成瘾研究中最有争议的结构。一方面是酗酒者的证词，渴望主宰了他们的思想，削弱了他们保持清醒的决心。另一方面，研究发现，渴望既不是必要的，也不足以解释饮酒。1996年，NIAAA召集了成瘾专家，以确定为什么渴望不是饮酒的可靠预测因素。该小组确定的知识库中的差距之一是渴望尚未在人类中得到充分的概念化和研究。缺乏这样的研究是一个重要的问题，因为它阻碍了对饮酒渴望的性质、过程、行为后遗症和调节功能的理解。我研究的长期目标是更好地理解渴望现象及其与饮酒和复发的关系。本申请的目的是检查两个有影响力的模型的渴望，渴望和药物使用的认知加工模型，和冲动和药物动机的双影响模型，这产生不同的预测之间的关联渴望和饮酒。这项研究的核心假设是，只有通过理论驱动的研究和使用范式，才能阐明在何种情况下渴望可能预测饮酒，这些范式可以操纵已知的引发饮酒的因素，并同时测量渴望和饮酒行为。三项研究提出了调查已知的因素，引起酗酒者饮酒，通过使用传统的线索反应性方法的创新修改线索可用性范式。研究一将探讨酒精启动和酒精可获得性对非寻求治疗的酗酒者的渴求、情感、酒精寻求和饮酒行为的影响。研究2将探讨消极情绪诱导和酒精可获得性对非寻求治疗的酗酒者的渴望、情感、酒精寻求和饮酒行为的影响。研究3将复制并添加到研究2的结果，通过提供线索可用性范式测量的饮酒行为的收敛有效性测试，以验证口味评级任务评估的类似措施。次要目的是测量参与这些实验室酒精给药研究对随后随意饮酒的影响。这项研究是创新的，因为它使用了一种范式，可以灵活地操纵已知影响酒精寻求和饮酒行为的因素，同时测量渴望和影响，并测试两种渴望模型。我们希望这项研究将提供重要的新信息，有关因素，适度的渴望，和渴望之间的关联和饮酒的人口的兴趣-酗酒。这项研究的主要影响将是解决人类渴望概念化知识库中的空白，这反过来将推动该领域的发展并为患者护理提供信息。