Genetic Recombination/Genomic Rearrangements Conference

基因重组/基因组重排会议

• 批准号: 6673102
• 负责人: SUSAN THOMAS LOVETT
• 金额: $ 0.7万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6673102
• 关键词: DNA repair; gene rearrangement; genetic recombination; meeting /conference /symposium; transposon /insertion element

DESCRIPTION (provided by applicant): This application requests partial funding for the 2003 and 2005 FASEB summer research conference on Genetic Recombination and Genomic Rearrangements. The 2003 conference will be held July 26-31 at Snowmass village, Colorado and will be the tenth of a highly successful series of bi-annual conferences on genetic recombination. These conferences join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will encourage discussion from all participants. Eight plenary sessions will involve topics such as recombination mechanisms, properties of prokaryotic and eukaryotic recombination, meiotic processes, the role of recombinational processes in repair of DNA damage, site-specific recombination and transposition, and genomic rearrangements. Forty speakers, among the best experimentalists and thinkers in these particular areas, have agreed to present their most recent and unpublished work. Several timely issues will be discussed including the role of the breast cancer susceptibility gene BRCA2 in the control of recombination, the role of recombination in repair of the replication fork and the cell cycle checkpoint response to DNA damage and its influence on repair and recombination. Characterization of recombination and repair factors known to underlie human syndromes will propensity to cancer will be discussed, using mammalian and other model genetic systems. Approximately 160 other participants will be chosen from among the applicants to the conference. While maintaining rigorous standards of excellence in selecting participants, every attention will be paid to achieving a balanced representation of age, gender, race and geography. All will be encouraged to participate in discussion, workshops and poster sessions. There will be a workshop on a controversial topic, the role of the Mus81 complexes in recombination intermediate processing, and two poster sessions, each lasting two days, will provide an additional forum for presentation of current work. The 2005 will be organized similarly but will feature different speakers. By emphasizing truly exceptional research in a modestly sized conference setting, the FASEB conference provide unique opportunities for the exchange of information, technology and perspective among new and established investigators in the recombination field.

描述（由申请人提供）：本申请要求为 2003 年和 2005 年 FASEB 夏季基因重组和基因组重排研究会议提供部分资金。 2003 年会议将于 7 月 26 日至 31 日在科罗拉多州斯诺马斯村举行，这将是一系列非常成功的基因重组两年两次会议中的第十次会议。 这些会议与研究人员一起在一系列生物系统中采用不同的实验方法研究基因重组的许多不同方面。 演讲将介绍有关该领域及时问题的新的和未发表的工作，并鼓励所有参与者进行讨论。 八场全体会议将涉及重组机制、原核和真核重组的特性、减数分裂过程、重组过程在DNA损伤修复中的作用、位点特异性重组和转座以及基因组重排等主题。 四十位演讲者，其中包括这些特定领域最优秀的实验家和思想家，同意展示他们最新且未发表的作品。 将讨论几个及时的问题，包括乳腺癌易感基因BRCA2在重组控制中的作用、重组在复制叉修复中的作用以及细胞周期检查点对DNA损伤的反应及其对修复和重组的影响。 将使用哺乳动物和其他模型遗传系统来讨论已知构成人类综合症的重组和修复因子的特征，这些因子将导致癌症倾向。 大约 160 名其他与会者将从会议申请者中选出。 在选择参与者时保持严格的卓越标准的同时，我们将竭尽全力实现年龄、性别、种族和地域的平衡代表性。 我们将鼓励所有人参与讨论、研讨会和海报会议。 将会有一个关于一个有争议的话题的研讨会，即 Mus81 复合物在重组中间处理中的作用，以及两个海报会议，每个会议持续两天，将为展示当前的工作提供一个额外的论坛。 2005 年的组织方式与此类似，但发言人有所不同。 通过在中等规模的会议环境中强调真正杰出的研究，FASEB 会议为重组领域的新老研究人员之间交流信息、技术和观点提供了独特的机会。