Penn State Summer Symposium in Molecular Biology

描述（由申请人提供）：部分支持是为第22届宾夕法尼亚州立大学夏季研讨会在分子生物学，会议题为“染色质结构和转录。“会议将于2003年7月30日至8月2日在宾夕法尼亚州立大学大学公园校园的尼塔尼狮子旅馆举行。 在过去的十年里，人们对染色质在真核细胞DNA功能各个方面的重要性的认识迅速增长。 染色质在转录中的作用的两个迅速发展的方面将是本次会议的双重焦点。 首先，组蛋白修饰及其逆转与基因调控有关，因为激活子和阻遏子已被证明是或募集，例如分别是乙酰化酶和脱乙酰化酶。 类似地，组蛋白甲基化、磷酸化和泛素化被转录调节因子提供和/或识别，并作为重要的表观遗传标记发挥作用。 视网膜母细胞瘤中的突变可以破坏Rb与脱乙酰酶的相互作用，脱乙酰酶抑制剂在某些肿瘤的治疗中显示出一定的实用性。 参与转录激活或抑制的其他染色质结构转换发生在大型多蛋白染色质重塑复合物的手中，其中最著名的是SWI/SNF。 BRCA 1与人类SWI/SNF相关复合物相关。 关于组蛋白修饰和重塑的会议将涉及这些研究领域的领导者，并将补充C。大卫阿利斯，组蛋白密码假说的创始人。 第二，广泛的新技术允许有意义的研究染色体背景下的长程相互作用和核结构组织在基因组的功能表达中的作用。 从遗传学到光漂白后荧光恢复的方法将在结构和核组织以及长距离染色体相互作用的两个平台会议上提出。 这些会议将补充Ulrich Laemmli的全体演讲。 同时下午的平台会议将允许36名初级研究人员向与会者介绍他们的研究;这些发言者将从他们的海报摘要中选出。 宾夕法尼亚州立大学研讨会的一个显着特点是靠近东海岸的大部分机构和学生的低成本，使他们特别受研究生和博士后研究员的欢迎和参加。

DESCRIPTION (provided by applicant): Partial support is requested for the 22nd Penn State Summer Symposium in Molecular Biology, a conference entitled "Chromatin Structure and Transcription." The conference will be held July 30-August 2, 2003 at the Nittany Lion Inn on Penn State's University Park campus. The past decade has witnessed burgeoning growth in realization of the importance of chromatin in all aspects of the function of DNA in eukaryotic cells. Two rapidly developing aspects of the role of chromatin in transcription will be the dual focal points for this meeting. First, histone modifications and their reversal have been implicated in gene regulation as activators and repressors have been shown either to be or to recruit, e.g. acetylases and deacetylases, respectively. Similarly, histone methylation, phosphorylation and ubiquitination are provided and/or recognized by transcription regulators and function as important epigenetic marks. Mutations in retinoblastoma can disrupt the interaction of Rb with deacetylases and deacetylase inhibitors have shown some utility in treatment of certain tumors. Other chromatin structural transitions involved in either activation or repression of transcription occur at the hands of large multiprotein chromatin remodeling complexes, the best known of which is SWI/SNF. BRCA1 is associated with a human SWI/SNF-related complex. Sessions on histone modification and remodeling will involve leaders in these areas of research and will complement the keynote address by C. David Allis, the originator of the histone code hypothesis. Second, a broad spectrum of novel techniques is allowing meaningful study of long range interactions in the chromosome context and the role of nuclear structural organization in the functional expression of the genome. Approaches ranging from genetics to fluorescence recovery after photobleaching will be presented in two platform sessions on structure and nuclear organization and long range chromosome interactions. These sessions will complement the plenary lecture by Ulrich Laemmli. Concurrent afternoon platform sessions will allow 36 junior investigators to present their research to the conferees; these speakers will be chose from abstracts of their posters. A notable feature of the Penn State Symposia in their proximity to a large segment of East coast institutions and the low cost for students, making them particularly popular with and well attended by graduate students and post-doctoral fellows.