New Perspectives in Transporter Biology-FASEB Conference

描述（由申请人提供）：本申请请求支持在美国实验生物学学会联合会（FASEB）主持下举行的题为“转运生物学新视角”的会议。“这是第四次关于这个问题的两年一度的FASEB会议，定于2003年7月5日至7月10日在亚利桑那州图森市的Omni Tucson举行。最近的事态发展将使会议引起广泛的调查人员的极大兴趣，我们预计将有大约160名科学家出席。这次会议将集中在运输蛋白在一些生物系统中的作用，从肾脏生理学到突触传递。在一个系统中阐明的原理已经开始帮助阐明膜运输在其他系统中的作用。此外，会议还将讨论转运蛋白在多个层面上的功能，从蛋白质结构到生物体的行为。高分辨率的生物物理学研究确实已经提出了各种转运蛋白的新作用，而这些作用是放射性示踪剂通量的经典测量所没有预料到的。因此，会议将为许多不同群体之间的互动提供一个不寻常的机会，包括生理学家，分子和细胞生物学家，生物化学家，生物化学家和结构生物学家。所涉及的生物学问题的范围也将鼓励不同群体之间的互动。除了转运蛋白在正常生理学中的作用外，会议还将考虑它们在疾病中的作用（例如，药物滥用和神经变性）和药物递送。会议将包括五天（上午和晚上）的九次口头科学会议和下午的海报会议。主题包括上皮运输，疾病中的运输，星形胶质细胞-神经元相互作用，通过膜运输和内在运输活动的变化调节转运蛋白，它们在信号传导中的作用，细胞内转运蛋白，转运机制和蛋白质结构。每次口头会议之后将进行专题小组讨论。为了促进初级教师的进步，最令人兴奋的海报提交将被选择在定期口头会议期间进行简短的口头陈述。

DESCRIPTION (provided by applicant): This application requests support of a conference to be held under the auspices of the Federation of American Societies of Experimental Biology (FASEB) entitled "New Perspectives in Transporter Biology." This is the fourth bi-annual FASEB conference on the subject and is scheduled to be held from July 5 - July 10, 2003 at the Omni Tucson, in Tucson Arizona. Recent developments will make the meeting of great interest to a wide range of investigators, and we expect attendance by approximately 160 scientists. This conference will focus on the role of transport proteins in a number of biological systems, from renal physiology to synaptic transmission. The principles elucidated in one system have already begun to help illuminate the role of membrane transport in others. In addition, the meeting will address the function of transport proteins at multiple levels, from protein structure to behavior of the organism. Biophysical studies at high resolution have indeed already suggested novel roles for various transport proteins not anticipated from classical measurements of radiotracer flux. The meeting will thus provide an unusual opportunity for interaction between many different groups, including physiologists, molecular and cell biologists, biochemists, biophysicists, and structural biologists. The range of biological questions addressed will also encourage interactions between diverse groups. In addition to the role of transporters in normal physiology, the meeting will consider their role in disease (e.g., drug abuse and neural degeneration) and in drug delivery. The conference will consist of nine oral scientific session over five days (morning and evening), and afternoon poster sessions. The topics include epithelial transport, transport in disease, astrocyte-neuron interactions, regulation of transporters by membrane trafficking and changes in intrinsic transport activity, their role in signalling, intracellular transporters, transport mechanism and protein structure. Each oral session will be followed by a panel discussion of the topic. To promote the advancement of junior faculty, the most exciting poster submissions will be selected for short oral presentations during the regular oral sessions.