2003 Hormonal Carcinogenesis Gordon Research Conference

描述（由申请人提供）：2003年激素致癌戈登研究会议的目标是为积极参与激素致癌各学科的现有和新研究者提供一个论坛，以共同确定该领域的前沿。主题将集中在主要激素相关的人类癌症，如乳腺癌、子宫内膜癌、卵巢癌和前列腺癌的研究现状，包括(1)核受体的结构/功能、受体-辅激活子相互作用和癌症中激素基因激活机制的研究现状；(2)激素合成与代谢的新进展；在癌变中的作用；肿瘤进展和/或癌症预防；(3)激素治疗与癌症风险；易感人群中激素诱发癌症的遗传决定因素(4)识别和理解细胞信号通路在细胞增殖和凋亡中的作用；(5)激素致癌的基因组学和蛋白质组学研究；(6)为激素和癌症研究提供合适的新型动物模型；(7)激素依赖型恶性肿瘤向激素非依赖型恶性肿瘤发展的基本原理和事件；(8)预防和治疗激素诱导癌症的新实验和/或介入方法。

DESCRIPTION (provided by applicant): The goal of the 2003 Hormonal Carcinogenesis Gordon Research conference is to provide a forum for established and new investigators who are actively involved in the various disciplines of hormonal carcinogenesis to come together to define the leading edges of the field. Topics will focus on current research on major hormone-related human cancers such as breast cancer, endometrial cancer, ovarian cancer and prostate cancer and will include (1) current research on the structure/function of nuclear receptors, receptor-coactivator interactions, and mechanisms of gene activation by hormones in cancers; (2) new developments in hormone biosynthesis and metabolism; roles in carcinogenesis; tumor progression, and/or prevention of cancer; (3) hormonal therapies and cancer risks; genetic determinants of hormone-induced cancers in susceptible populations; (4) identification and understanding of the role of cell signaling pathways in proliferation and apoptosis; (5) genomic and proteomic approaches in hormonal carcinogenesis; (6) appropriate and novel animal models for research in hormones and cancer; (7) basic principles and events of progression from hormone-dependent to hormone-independent malignancies; and (8) new experimental and/or interventional approaches to prevention and treatment of hormone-induced cancers. Emerging areas and late-breaking topics are added to help conferees stay abreast with new opportunities in the field, and poster sessions will enable informal interactions to occur. Because of the multi-disciplinary nature of hormonal carcinogenesis, this conference brings together an unusually diverse collection of investigators and participants, including senior, authoritative investigators as well as new investigators and junior scientists. The overall objective is to stimulate new ideas, discover novel paradigms, share technological advances, promote collaborations and interactions, and recognize historical landmarks of discoveries in this field. The conference will allow participants to be updated on the latest developments in this increasingly complex research area, to recognize the significance of recent accomplishments, to devise and share new strategies for unresolved problems, and to critically evaluate existing theories and develop new hypotheses.