RNA Trafficking, Transport and Processing

RNA 贩运、运输和加工

• 批准号: 6585420
• 负责人: ANNE EPHRUSSI
• 金额: $ 0.8万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585420
• 关键词: genetic transcription; genetic translation; intracellular transport; meeting /conference /symposium; messenger RNA; posttranscriptional RNA processing; travel

Recent exciting developments in the field of RNA transport have revealed that RNA processing, exit from the nucleus and identification in the cytoplasm are related processes, mediated by highly dynamic protein-RNA interactions. Proteins deposited on RNAs co-transcriptionally and through splicing appear to be critical to the subsequent fate of mRNA. Although their functions and to some extent even their identities are not clear, these proteins determine the properties of the mRNA with which they associate. They affect the nuclear export, stability and likely other cytoplasmic aspects of the life of an mRNA. The nuclear RNP remodeling events, how very large mRNP complexes get through the nuclear pore, how they associate with the cytoskeletal components required for their localization, how specificity of localization is determined and how translational repression of the unlocalized mRNA and local translational activation are achieved are now among the central questions. The goal of this meeting is to bring together scientists working at each level in the metabolism of mRNA, from it's co-transcriptional processing to its eventual translation and stability properties. It is at the interfaces between these different sub-disciplines that we hope to encourage interaction between scientists at the forefront and stimulate progress of this central and highly dynamic field. The goal of this meeting is to bring together scientists at the forefront of the RNA trafficking field, which is currently witnessing an explosion of developments with important medical ramifications. Indeed, the central role of post-transcriptional gene regulation effected at the RNA level is highlighted by the increasing number of pathologies whose basis is found to lie in some aspect of RNA control. Although many conferences include topics that deal with RNA, and one annually recurrent event, the RNA Society Meeting, deals with all aspects of RNA, this meeting is the only one we are aware of whose central focus is around RNA trafficking - how, once synthesized, RNA is dealt with by the cell to perform its functions optimally in the cytoplasm.

RNA转运领域的最新令人兴奋的发展表明，RNA处理，从细胞核中退出和细胞质中的鉴定是相关的过程，是由高度动态的蛋白RNA相互作用介导的。 通过剪接沉积在RNA上的蛋白质似乎对于随后的mRNA命运至关重要。 尽管它们的功能和在某种程度上尚不清楚，但这些蛋白质决定了与之关联的mRNA的特性。 它们会影响mRNA生命的核出口，稳定性以及可能的其他细胞质方面。 核RNP重塑事件，非常大的MRNP复合物如何通过核孔，它们如何与其本地化所需的细胞骨架成分相关联，如何确定定位的特异性以及如何在中心问题中实现未定位的MRNA和局部翻译激活的转化抑制。 这次会议的目的是将在mRNA代谢的每个层面工作，从共同的转录处理到其最终的翻译和稳定性。 我们希望在这些不同的子学科之间的界面上鼓励科学家之间的相互作用，并刺激这个中心和高度动态的领域的进步。 这次会议的目的是将科学家汇集到RNA贩运领域的最前沿，目前正在目睹具有重要医疗后果的发展的爆炸。 实际上，在RNA水平上产生的转录后基因调节的核心作用是由越来越多的病理数量强调了，这些病理的基础在RNA控制的某些方面被发现。 尽管许多会议都包括涉及RNA的主题，以及每年一次的RNA协会会议，涉及RNA的各个方面，但这次会议是我们唯一知道其唯一围绕RNA围绕RNA贩运的焦点 - 一旦合成，RNA如何由细胞处理在细胞质中发挥作用。