EBV and HPV: Oral Infection, Persistence & Pathogenesis

EBV 和 HPV：口腔感染、持续性

• 批准号: 6560497
• 负责人: DENNIS M WALLING
• 金额: $ 2万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-01 至 2003-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6560497
• 关键词: Epstein Barr virus; health science research; human papillomavirus; meeting /conference /symposium; pathologic process; travel; virus infection mechanism; virus related neoplasm /cancer

DESCRIPTION (provided by applicant): Epstein-Barr virus (EBV) and human papillomavirus (HPV) are two important human tumor viruses that cause significant human disease morbidity and mortality worldwide. Recent data suggest that EBV and HPV are important, but under-appreciated, causes of disease in the oral cavity. To bring more clinical and research attention to EBV and HPV oral epithelial infection and disease pathogenesis, a major international scientific meeting will be convened February 13-16, 2003, in Galveston, Texas, entitled: "EBV and HPV: Oral Infection, Persistence, and Pathogenesis". The goal of this meeting will be to promote a multi-disciplinary examination of EBV and HPV disease pathogenesis in oral mucosal epithelium that will develop new scientific hypotheses and will catalyze new inter-disciplinary research initiatives in this field. This goal will be achieved by 1) identifying the important deficits in our current knowledge, 2) identifying areas of scientific and clinical overlap between disciplines, and 3) promoting new research collaborations between investigators. The meeting is designed as a symposium for 200 participants. It will be small and intimate enough to facilitate interaction, discussion, and networking, yet large enough with a critical intellectual mass to be catalytic in developing new ideas and new research relationships. Invited speakers and participants will come from around the world and will represent various clinical and scientific disciplines, including infectious diseases, virology, oral medicine, oral pathology, epithelial biology, mucosal immunology, oncogenesis, and environmental mutagenesis. The scientific agenda will include five major scientific sessions organized into distinct biologic and pathogenic themes: 1) Prerequisites for Pathogenesis: Viral Epithelial Infection and Persistence; 2) Achieving the Balance: Mucosal Immunity and Viral Persistence; 3) From Correlation to Causality: Viral Epithelial Disease Pathogenesis; 4) The Multi-Step Hypothesis: Epithelial Cell Molecular Oncogenesis; and 5) From Bench to Bedside: Epithelial Disease Prevention and Treatment. The support of an NIH R13 grant would potentially bring more investigators to this field by providing funds to allow students (graduate, medical, and dental), post-doctoral fellows, and young investigators to attend this important meeting.

描述（由申请人提供）：EB病毒（EBV）和人乳头瘤病毒（HPV）是两种重要的人类肿瘤病毒，在全球范围内引起显著的人类疾病发病率和死亡率。最近的数据表明，EBV和HPV是重要的，但未被充分认识的口腔疾病的原因。为了使更多的临床和研究关注EBV和HPV口腔上皮感染和疾病发病机制，将于2003年2月13-16日在德克萨斯州的加尔维斯顿召开一次重要的国际科学会议，题为“EBV和HPV：口腔感染、持续性和发病机制”。本次会议的目标是促进对口腔粘膜上皮中EBV和HPV疾病发病机制的多学科研究，这将发展新的科学假设，并将促进该领域新的跨学科研究计划。这一目标将通过以下方式实现：1）确定我们现有知识中的重要缺陷，2）确定学科之间的科学和临床重叠领域，3）促进研究者之间的新研究合作。 这次会议是一次可容纳200人的专题讨论会。它将足够小和亲密，以促进互动，讨论和网络，但足够大，具有关键的知识质量，在发展新的想法和新的研究关系中起催化作用。特邀演讲者和参与者将来自世界各地，将代表各种临床和科学学科，包括传染病，病毒学，口腔医学，口腔病理学，上皮生物学，粘膜免疫学，肿瘤发生和环境诱变。科学议程将包括五个主要的科学会议，分为不同的生物学和病原学主题：1）预防发病机制：病毒上皮感染和持久性; 2）实现平衡：粘液免疫和病毒持久性; 3）从相关性到因果关系：病毒上皮疾病发病机制; 4）多步骤假设：上皮细胞分子致癌;和5）从实验室到床边：上皮疾病的预防和治疗。美国国立卫生研究院R13赠款的支持可能会带来更多的研究人员到这一领域提供资金，让学生（研究生，医学和牙科），博士后研究员和年轻的研究人员参加这一重要会议。