Expanding the scope of metal catalysed DNA-encoded library synthesis

DNA编码文库（DELs）为药物发现和化学生物学提供了一种令人兴奋的快速和经济有效的鉴定命中化合物的新技术。目前，可用于筛选的化合物库受到可以在DNA缀合的底物上进行的化学范围的限制。我们将使用新方法扩展可用于生成DEL的化学方法，以实现一系列金属催化转化，包括在传统DEL条件下不可靠的反应。该方法将应用于DEL合成，以建立范围并生成用于筛选新蛋白质靶点的文库。

DNA encoded libraries (DELs) offer an exciting new technology for the rapid and cost-effective identification of hit compounds for drug discovery and chemical biology. Currently the libraries of compounds available to screen are limited by the range of chemistry that can be carried out on DNA-conjugated substrates. We will expand the chemistry available for generating DELs using new approaches to a range of metal-catalysed transformations, including reactions that are unreliable under traditional DEL conditions. The methodology will be applied to DEL synthesis to establish the scope and to generate libraries for screening against novel protein targets.