Expanding the scope of metal catalysed DNA-encoded library synthesis

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DNA encoded libraries (DELs) offer an exciting new technology for the rapid and cost-effective identification of hit compounds for drug discovery and chemical biology. Currently the libraries of compounds available to screen are limited by the range of chemistry that can be carried out on DNA-conjugated substrates. We will expand the chemistry available for generating DELs using new approaches to a range of metal-catalysed transformations, including reactions that are unreliable under traditional DEL conditions. The methodology will be applied to DEL synthesis to establish the scope and to generate libraries for screening against novel protein targets.