Exercise and Cognitive Aging

运动和认知老化

• 批准号: 6814467
• 负责人: ROBERT KRIKORIAN
• 金额: $ 15.55万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-15 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6814467
• 关键词: Alzheimer' s disease; aerobic exercise; aging; clinical research; cognition; cognition disorders; cortisol; glucocorticoids; hippocampus; human subject; human therapy evaluation; memory; neocortex; nervous system disorder therapy; neurogenesis; neurotrophic factors; patient oriented research

DESCRIPTION (provided by applicant): This grant application seeks support to develop preliminary data concerning a behavioral intervention aimed at ameliorating age-associated cognitive decline. It will investigate the effect of an aerobic fitness intervention on cognitive function in elderly individuals with Mild Cognitive Impairment (MCI). MCI has been recognized as a transitional condition in the development of Alzheimer's Disease (AD). Recent studies have shown that aerobic exercise potentiates neurogenesis in the hippocampus and neocortex and enhances cognitive abilities mediated by these brain structures in elderly adults. Exercise also has been shown to increase neurotrophic factors. Furthermore, inverse relationships have been observed in the aged between glucocorticoid levels and hippocampal and neocortical integrity, and elevations of cortisol have been implicated in AD. We propose an exploratory study evaluating the efficacy of an aerobic exercise intervention in enhancing cognitive function in MCI. A secondary goal is assessment of the effect of the intervention on modulation of basal cortisol level, an indirect index of hippocampal and neocortical integrity. In a randomized, controlled study, we will conduct a 12-week aerobic conditioning program with previously sedentary men and women with Mild Cognitive Impairment. We will investigate changes in executive function ability, episodic memory function, and basal cortisol. Changes in mood, cardiac function, and aerobic capacity also will be assessed as possible mediating factors. The findings of this study would represent an initial but essential step in evaluating the efficacy of aerobic exercise as a behavioral factor that ultimately might be found to delay, arrest, or conceivably reverse progression of age-related cognitive decline. It also would yield data indicating the effectiveness of the intervention in modulating cortisol, elevation of which is associated with substantial risk for cerebral deterioration in the elderly. The demonstration of an ameliorating effect would provide the basis for future investigations examining the specific nature of the cognitive-cerebral adaptations to exercise, the relative benefits of different forms of exercise, and issues of dosage and duration of effect.

描述（由申请人提供）：本赠款申请寻求支持以制定有关旨在改善年龄相关认知能力下降的行为干预措施的初步数据。它将研究有氧健身干预对患有轻度认知障碍（MCI）的老年人认知功能的影响。 MCI被认为是阿尔茨海默氏病（AD）发展的过渡条件。最近的研究表明，有氧运动增强了海马和新皮层的神经发生，并增强了这些大脑结构在老年人中介导的认知能力。运动也已被证明会增加神经营养因素。此外，在糖皮质激素水平与海马和新皮质完整性之间的年龄中观察到了反比关系，皮质醇的升高与AD有关。我们提出了一项探索性研究，评估有氧运动干预在增强MCI认知功能方面的功效。第二个目标是评估干预措施对基底皮质醇水平调节的影响，这是海马和新皮质完整性的间接指数。在一项随机，对照研究中，我们将进行为期12周的有氧运动调节计划，以前久坐的男性和女性具有轻度的认知障碍。我们将研究执行功能能力，情节记忆功能和基础皮质醇的变化。情绪，心脏功能和有氧运动能力的变化也将作为可能的中介因子评估。这项研究的发现将代表评估有氧运动的疗效作为行为因素的最初但必不可少的步骤，最终可能会发现与年龄相关的认知能力下降的延迟，停滞或可以逆转。它还产生数据，表明干预措施调节皮质醇的有效性，其升高与老年人的大脑恶化相关。改善效果的演示将为未来的研究提供基础，以研究认知脑型适应运动的特定性质，不同形式的运动的相对好处以及剂量和效果持续时间的问题。