FILAMENTOUS INFLUENZA VIRUS AND MICROBIAL COLONIZATION

丝状流感病毒和微生物定植

• 批准号: 6803560
• 负责人: P. CHRIS ROBERTS
• 金额: $ 18.88万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2006-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6803560
• 关键词: Streptococcus pneumoniae; Streptococcus pyogenes; bacterial pneumonia; bacterial proteins; disease /disorder proneness /risk; influenza; mucins; mucosa; protein binding; receptor binding; respiratory epithelium; respiratory infections; secondary infection; tissue /cell culture; virion; virus infection mechanism; virus receptors; virus replication

DESCRIPTION (provided by applicant): Individuals recovering from influenza A virus infection demonstrate an increased susceptibility to secondary bacterial pulmonary infections, particularly with the pathogens Streptococcus pyogenes and Streptococcus pneumoniae. Quite often, these secondary bacterial pneumonias are fatal, especially in geriatric and immunocompromized patients. The mechanism(s) behind this increased susceptibility to a secondary streptococcal infection are unknown. We hypothesize that this increased susceptibility to bacterial super-infection is due to a filamentous form of influenza A virus significantly facilitating the adhesion of pathogenic streptococci to respiratory mucosa. Experiments in this application will determine if filamentous influenza A virus can directly serve as a receptor for bacterial binding or if the respiratory mucosa is altered by infection with influenza virus to promote increased bacterial adherence. In parallel, we will also determine whether prior bacterial colonization can affect influenza virus replication in respiratory epithelium.

描述（由申请人提供）： 从甲型流感病毒感染中恢复的个体表现出对继发性细菌性肺部感染的易感性增加，特别是病原体化脓性链球菌和肺炎链球菌。 这些继发性细菌性肺炎通常是致命的，特别是在老年和免疫功能低下的患者中。继发性链球菌感染易感性增加的机制尚不清楚。 我们推测，这种增加的易感性细菌的双重感染是由于丝状形式的甲型流感病毒显着促进致病性链球菌粘附到呼吸道粘膜。 本申请中的实验将确定丝状甲型流感病毒是否可以直接作为细菌结合的受体，或者呼吸道粘膜是否因流感病毒感染而改变以促进细菌粘附增加。同时，我们还将确定先前的细菌定植是否会影响流感病毒在呼吸道上皮中的复制。