Understanding metabolism for biotechnology in the green alga Chlamydomonas reinhardtii

了解绿藻莱茵衣藻生物技术的代谢

• 批准号: 2282498
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2282498
• 关键词: Understanding; metabolism; biotechnology; green; alga

The green alga Chlamydomonas has the potential to be an important source of high value biochemicals and to be used in the production of biofuels. Manipulating its metabolism to optimise the production of particular types of molecule requires however an understanding of that metabolism which we do not yet have. This project will combine mathematical modelling of cellular metabolism, using constraint-based and kinetic models, with physiological and molecular manipulation of cell growth, to gain insights into factors regulating the partitioning of photosynthetically fixed carbon between different metabolic pathways.

绿藻衣藻有可能成为高价值生物化学品的重要来源，并用于生产生物燃料。然而，操纵其新陈代谢以优化特定类型分子的生产需要对这种新陈代谢的了解，而这是我们还不知道的。该项目将使用基于约束的模型和动力学模型，将细胞代谢的数学模型与细胞生长的生理和分子操作结合起来，以深入了解调节不同代谢途径之间光合作用固定碳分配的因素。