Respiratory Triggers and Sensory Irritation: Role of Environmental Pollution in Respiratory Symptoms

呼吸触发和感觉刺激：环境污染在呼吸道症状中的作用

• 批准号: 2282965
• 金额: --
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2282965
• 关键词: Respiratory; Triggers; Sensory; Irritation; Role

To investigate the effects of environmental pollutants on sensory nerves and the subsequent role in the initiation or exacerbation of respiratory symptoms (inflammatory responses/cough/bronchospasm). The contribution of TRP channel activation (starting with those identified by our group and others on airway afferents e.g. TRPV1, TRPA1, TRPV4, TRPM3, TRPM8) in these events will be studied. To investigate these mechanisms, we will be using a range of techniques including in vivo and in vitro electrophysiology, novel ex vivo cell and tissue models, state-of-the-art cellular imaging and animal model systems. Insight into the mechanisms behind environmental influences on such biological process could reveal novel therapeutic strategies, whilst highlighting unwanted features of various products present in the environment.

研究环境污染物对感觉神经的影响以及随后在呼吸道症状（炎症反应/咳嗽/支气管痉挛）的发生或加重中的作用。将研究TRP通道激活（从我们小组和其他人对气道传入的识别开始，例如TRPV 1，TRPA 1，TRPV 4，TRPM 3，TRPM 8）在这些事件中的作用。为了研究这些机制，我们将使用一系列技术，包括体内和体外电生理学，新型离体细胞和组织模型，最先进的细胞成像和动物模型系统。深入了解环境对这种生物过程的影响背后的机制可以揭示新的治疗策略，同时突出环境中存在的各种产品的不必要特征。