FACILITY CONSTRUCTION EXPANSION- MONNELL CHEMICAL SENSES

描述（由申请人提供）： Monell化学感官中心（MCSC）于1968年成立，是一家非营利性的科学研究机构，如今已成为化学感官（味觉、嗅觉和化学刺激）基础和临床研究领域的全球领导者。美国国立卫生研究院（NIH）估计，在美国，化学感觉的改变或丧失可能严重到足以让600万人在一生中寻求医疗照顾。 该中心唯一的一座大楼现已全部占用，限制了本组织一贯的稳定增长。 两个项目显示出显着的增长-分子生物学和人类感官知觉目前有高生产力的研究人员谁拥有多个国家卫生研究院的奖项，没有实验室可供新的工作人员，也没有扩大现有的项目。 为了进一步了解化学感官和扩大中心的研究前景，该申请寻求资金：1）翻新空间，创造一个7,200平方米。英尺化学传感分子基因组学和蛋白质组学设施; 2）扩大7，200人 平方英尺，并翻新该中心的人类化学传感器研究设施;和3）提供足够的供暖，通风和空调系统，以支持这些研究工作的关键需求。 该中心是一个独特的，专注的实体，专门致力于优秀的生物医学和行为研究和培训。 这一拟议的扩建将加强该研究所，改善公共卫生，并使科学界的一大部分人受益。 国家研究资源中心（NCRR）的400万美元资金，以及Monell的400多万美元资金，被要求建立一个化学传感分子基因组学和蛋白质组学设施和一个人类化学传感研究设施。

DESCRIPTION (provided by applicant): Expansion of the Monell Chemical Senses Center (MCSC), chartered in 1968 as a non-profit scientific research institute, is today the world's leader in basic and clinical studies of the chemical senses: taste, olfaction and chemical irritation. National Institutes of Health (NIH) estimates that in the United States of America (USA), alterations or loss of the chemical senses can be severe enough to have six million individuals seek medical attention during their lifetime. The Center's only building is now completely occupied, limiting the steady growth that has been characteristic of the organization. Two programs showing significant growth - molecular biology and human sensory perception currently have highly productive investigators who have multiple NIH awards with no laboratories available for new staff nor for expansion of existing projects. In order to further an understanding of the chemical senses and expand the Center's research outlook, this application seeks funds to: 1) renovate space to create an 7,200 sq. ft. facility for Chemosensory Molecular Genomics and Proteomics; 2) expand by 7,200 sq. ft, and renovate the Center's Human Chemosensory Research Facility; and 3) provide adequate heating, ventilating, and air-conditioning systems to support the critical needs of these research endeavors. The Center is a unique, focused entity devoted exclusively to outstanding biomedical and behavioral research and training. This proposed expansion will strengthen the institute, improve public health, and benefit a large cross-section of the scientific community. Four million dollars in National Center for Research Resources (NCRR) funding, matched by more than $4 million in Monell funding, are requested to construct a Chemosensory Molecular Genomics and Proteomics Facility and a Human Chemosensory Research Facility.