Correlates of Duration of Initial Untreated Psychosis

描述（由申请人提供）：这个以患者为导向的指导研究职业发展奖将为康普顿博士作为一名独立的临床研究科学家的发展提供支持。他的培训目标是：(1)获得针对精神分裂症患者及其家庭的实证临床研究的规划、设计、实施和评估的实践经验；(2)继续进行数据分析、结果解释和研究成果传播方面的培训；(3)学习与精神分裂症谱系障碍参与者及其家庭进行道德健全、文化胜任的研究的必要技能；(4)获得以预防为导向的科学探究方面的专业知识，特别是在以二级预防为导向的精神分裂症研究领域；(5)将实证研究与公共卫生观点结合起来，包括将研究结果转化为临床实践和适当的社区政策变化。康普顿博士是一名精神病学家和预防医学医师，他的首要科学目标是追求以预防为导向的精神分裂症研究。该K23应用以二级预防范式和生态概念模型为指导，通过研究与精神分裂症初始阶段寻求早期评估和干预延迟相关的预测因素和结果。康普顿博士提出的研究将调查对未治疗精神病（DUP）持续时间的潜在影响的三个领域：父母/家庭因素、患者/疾病因素和服务/系统因素。为此，他将招募100名首发精神分裂症谱系障碍患者，在他们第一次住院期间对他们进行评估。康普顿博士还将对200名亲属和其他线人进行横断面评估，以研究可能与DUP时间长短相关的因素。此外，他将采用纵向研究设计，从患者首次住院开始，连续两年对患者进行评估，研究可能与初始精神病（DDIP）持续时间和剂量相关的各种结果，DDIP是一种测量初始精神病累积暴露（急性症状消退前的持续时间，以及症状的频率和强度）的拟议结构。该研究项目的总体目标是为首次发作的精神病患者提供一个深入的潜在原因和后果的初步治疗的探索。

DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award will provide support for Dr. Compton's development as an independent clinical research scientist. His training goals are as follows: (1) to acquire practical experience in the planning, design, implementation, and evaluation of empirical clinical research with individuals with schizophrenia and their families; (2) to continue training in data analysis, interpretation of results, and dissemination of research findings; (3) to learn the necessary skills for ethically sound, culturally competent research with participants with schizophrenia-spectrum disorders and their families; (4) to gain expertise in prevention-oriented scientific inquiry, especially in the area of secondary prevention-oriented schizophrenia research; and (5) to combine empirical research with a public health perspective, including the translation of findings into clinical practice and appropriate community-level policy changes. Dr. Compton is a psychiatrist and a preventive medicine physician, and his overarching scientific objective is to pursue prevention-oriented schizophrenia research. This K23 application is guided by a secondary prevention paradigm and an ecological conceptual model by studying predictors and outcomes associated with delays in seeking early evaluation and intervention during the initial phases of schizophrenia. Dr. Compton's proposed research will investigate three domains of potential influence on the duration of untreated psychosis (DUP): parent/family factors, patient/illness factors, and services/systems factors. To do so, he will recruit 100 patients with a first-episode of a schizophrenia-spectrum disorder, who will be assessed during their first hospitalization. Dr. Compton will also evaluate cross-sectionally 200 relatives and other informants for his study of factors that may be associated with the length of the DUP. Additionally, he will use a longitudinal research design to sequentially assess the patients for two years from the time of their first hospitalization, to study a variety of outcomes that may be related to the duration and dose of initial psychosis (DDIP), a proposed construct that measures cumulative exposure to initial psychosis (duration until resolution of acute symptoms, and frequency and intensity of symptoms). The overall aim of the research project is to provide an in-depth exploration of the potential causes and consequences of initially untreated psychosis among first-episode patients.