Correlates of Duration of Initial Untreated Psychosis

初始未治疗精神病持续时间的相关性

• 批准号: 7113629
• 负责人: MICHAEL T COMPTON
• 金额: $ 16.55万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-06 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7113629
• 关键词: adult human (21+); behavioral /social science research tag; clinical research; coping; data collection methodology /evaluation; disease /therapy duration; family genetics; family structure /dynamics; health behavior; health care service availability; health care service utilization; health insurance; interpersonal relations; longitudinal human study; mental disorder chemotherapy; mental health education; neuropsychological tests; outcomes research; patient oriented research; psychosocial separation; psychotherapy; quality of life; schizophrenia; social psychology; social support network; socioeconomics

DESCRIPTION (provided by applicant): This Mentored Patient-Oriented Research Career Development Award will provide support for Dr. Compton's development as an independent clinical research scientist. His training goals are as follows: (1) to acquire practical experience in the planning, design, implementation, and evaluation of empirical clinical research with individuals with schizophrenia and their families; (2) to continue training in data analysis, interpretation of results, and dissemination of research findings; (3) to learn the necessary skills for ethically sound, culturally competent research with participants with schizophrenia-spectrum disorders and their families; (4) to gain expertise in prevention-oriented scientific inquiry, especially in the area of secondary prevention-oriented schizophrenia research; and (5) to combine empirical research with a public health perspective, including the translation of findings into clinical practice and appropriate community-level policy changes. Dr. Compton is a psychiatrist and a preventive medicine physician, and his overarching scientific objective is to pursue prevention-oriented schizophrenia research. This K23 application is guided by a secondary prevention paradigm and an ecological conceptual model by studying predictors and outcomes associated with delays in seeking early evaluation and intervention during the initial phases of schizophrenia. Dr. Compton's proposed research will investigate three domains of potential influence on the duration of untreated psychosis (DUP): parent/family factors, patient/illness factors, and services/systems factors. To do so, he will recruit 100 patients with a first-episode of a schizophrenia-spectrum disorder, who will be assessed during their first hospitalization. Dr. Compton will also evaluate cross-sectionally 200 relatives and other informants for his study of factors that may be associated with the length of the DUP. Additionally, he will use a longitudinal research design to sequentially assess the patients for two years from the time of their first hospitalization, to study a variety of outcomes that may be related to the duration and dose of initial psychosis (DDIP), a proposed construct that measures cumulative exposure to initial psychosis (duration until resolution of acute symptoms, and frequency and intensity of symptoms). The overall aim of the research project is to provide an in-depth exploration of the potential causes and consequences of initially untreated psychosis among first-episode patients.

描述（由申请人提供）：这项以患者为导向的研究职业发展奖将为康普顿博士作为独立临床研究科学家的发展提供支持。培训目标如下：（1）获得针对精神分裂症患者及其家属的实证临床研究的规划、设计、实施和评估的实践经验； (2) 继续进行数据分析、结果解释和研究成果传播方面的培训； (3) 与精神分裂症谱系障碍患者及其家人一起学习必要的技能，以便进行道德上健全、文化上合格的研究； (4) 获得以预防为导向的科学探究方面的专业知识，特别是在以二级预防为导向的精神分裂症研究领域； (5) 将实证研究与公共卫生视角相结合，包括将研究结果转化为临床实践和适当的社区层面的政策变化。康普顿博士是一名精神病学家和预防医学医师，他的首要科学目标是进行以预防为导向的精神分裂症研究。该 K23 应用程序以二级预防范式和生态概念模型为指导，通过研究与精神分裂症初始阶段寻求早期评估和干预延迟相关的预测因素和结果。康普顿博士提出的研究将调查对未经治疗的精神病 (DUP) 持续时间产生潜在影响的三个领域：父母/家庭因素、患者/疾病因素和服务/系统因素。为此，他将招募 100 名首发精神分裂症谱系障碍患者，并在他们首次住院期间接受评估。康普顿博士还将对 200 名亲属和其他知情人进行横断面评估，以研究可能与 DUP 长度相关的因素。此外，他将使用纵向研究设计，从患者首次住院起连续两年评估患者，研究可能与初始精神病持续时间和剂量（DDIP）相关的各种结果，DDIP是一种拟议的测量初始精神病累积暴露（直到急性症状消退的持续时间，以及症状的频率和强度）的结构。该研究项目的总体目标是深入探讨首发患者中最初未经治疗的精神病的潜在原因和后果。