Personality, anxiety, and depression in community adults

这是一份修改后的K23申请，其目的是为候选人在人格、焦虑和抑郁障碍的遗传流行病学方面的独立职业做准备。该研究项目的总体重点是确定人格特征与焦虑和抑郁障碍之间的关系。目前在一般人群中很少有关于这种关系的经验数据，特别是纵向视角，多种评估方法和遗传信息性。这项拟议的研究为调查这些问题提供了一个独特的机会，使用了巴尔的摩流行病学流域（ECA）研究、弗吉尼亚双胞胎研究（VTS）和弗吉尼亚双胞胎青少年家庭研究的数据

This is a revised K23 application, the purpose of which is to prepare the candidate for an independent career in the genetic epidemiology of personality and anxiety and depressive disorders. The overall focus of the research project is to determine how personality traits and anxiety and depressive disorders relate. There is currently little empirical data regarding such relationships in the general population, especially with a longitudinal perspective, multiple methods of assessment, and genetic informativeness. The proposed study provides a unique opportunity to investigate these issues, using data from the Baltimore Epidemiologic Catchment (ECA) Study, The Virginia Twin Study (VTS), and The Virginia Twin-Family Study of Adolescent Behavioral Development (v-rSABD). The specific aims of this proposal are: 1) To determine longitudinal relationships between normal personality traits and anxiety and depressive disorders, using data from the Baltimore ECA, V'I'S, and VTSABD cohorts; 2) To determine longitudinal relationships between personality disorder traits and anxiety and depressive disorders in adults, using data from the Baltimore ECA cohort; 3) To determine associations between personality traits and treatment seeking, using data from the Baltimore ECA cohort; and 4) To determine to what extent associations between neuroticism and extraversion and anxiety and depressive disorders reflect common genetic or environmental determinants, using data from the V'I'S and VTSABD cohorts. The products will include an enhanced understanding of the influence of personality traits on risk for and persistence of anxiety and depressive disorders, new information on the risk of development of personality disorder traits in adulthood as a complication of anxiety and depressive disorders, new knowledge regarding the influence of personality traits on treatment seeking, and a more detailed understanding of etiologic relationships between normal personality traits and anxiety and depressive disorders. The results will have implications for prevention and other public health efforts. The Principal Investigator's research career development will be enhanced substantially through protected time for mentored analyses of longitudinal and twin data, and for relevant coursework. He will be guided by exceptionally talented mentors, including Drs. Gerald Nestadt, Kenneth Kendler, William Eaton, Kung-Yee Liang, Paul Costa, Murray Stein, Patrick Sullivan, and Lindon Eaves.