Personality, anxiety, and depression in community adults

社区成年人的性格、焦虑和抑郁

• 批准号: 6931541
• 负责人: O. Joseph BIENVENU
• 金额: $ 16.92万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-12 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6931541
• 关键词: anxiety disorders; behavioral /social science research tag; cyclothymia; data management; depression; disease /disorder etiology; disease /disorder onset; genetic susceptibility; health care service utilization; human data; longitudinal human study; mental health epidemiology; patient oriented research; personality; personality disorders

This is a revised K23 application, the purpose of which is to prepare the candidate for an independent career in the genetic epidemiology of personality and anxiety and depressive disorders. The overall focus of the research project is to determine how personality traits and anxiety and depressive disorders relate. There is currently little empirical data regarding such relationships in the general population, especially with a longitudinal perspective, multiple methods of assessment, and genetic informativeness. The proposed study provides a unique opportunity to investigate these issues, using data from the Baltimore Epidemiologic Catchment (ECA) Study, The Virginia Twin Study (VTS), and The Virginia Twin-Family Study of Adolescent Behavioral Development (v-rSABD). The specific aims of this proposal are: 1) To determine longitudinal relationships between normal personality traits and anxiety and depressive disorders, using data from the Baltimore ECA, V'I'S, and VTSABD cohorts; 2) To determine longitudinal relationships between personality disorder traits and anxiety and depressive disorders in adults, using data from the Baltimore ECA cohort; 3) To determine associations between personality traits and treatment seeking, using data from the Baltimore ECA cohort; and 4) To determine to what extent associations between neuroticism and extraversion and anxiety and depressive disorders reflect common genetic or environmental determinants, using data from the V'I'S and VTSABD cohorts. The products will include an enhanced understanding of the influence of personality traits on risk for and persistence of anxiety and depressive disorders, new information on the risk of development of personality disorder traits in adulthood as a complication of anxiety and depressive disorders, new knowledge regarding the influence of personality traits on treatment seeking, and a more detailed understanding of etiologic relationships between normal personality traits and anxiety and depressive disorders. The results will have implications for prevention and other public health efforts. The Principal Investigator's research career development will be enhanced substantially through protected time for mentored analyses of longitudinal and twin data, and for relevant coursework. He will be guided by exceptionally talented mentors, including Drs. Gerald Nestadt, Kenneth Kendler, William Eaton, Kung-Yee Liang, Paul Costa, Murray Stein, Patrick Sullivan, and Lindon Eaves.

这是一份修订后的K23申请，其目的是为候选人在人格、焦虑和抑郁障碍的遗传流行病学方面的独立职业生涯做准备。该研究项目的总体重点是确定人格特征与焦虑和抑郁障碍之间的关系。目前，关于普通人群中这种关系的经验数据很少，特别是在纵向视角、多种评估方法和遗传信息性方面。拟议的研究提供了一个独特的机会来调查这些问题，使用来自巴尔的摩流行病学流域(ECA)研究、弗吉尼亚双胞胎研究(VTS)和弗吉尼亚双胞胎家庭青少年研究的数据 行为发育(v-rSABD)。这项建议的具体目标是：1)使用巴尔的摩ECA、V‘S和VTSABD队列的数据，确定正常人格特征与焦虑和抑郁障碍之间的纵向关系；2)使用巴尔的摩ECA队列的数据，确定成人人格障碍特征与焦虑和抑郁障碍之间的纵向关系；3)使用巴尔的摩ECA队列的数据，确定人格特征和寻求治疗之间的关联；以及4)确定神经质和外倾之间的关联程度 焦虑和抑郁障碍反映了常见的遗传或环境决定因素，使用来自V‘S和VTSABD队列的数据。这些成果将包括加强对人格特征对焦虑和抑郁障碍的风险和持久性的影响的了解，关于成年后人格障碍特征作为焦虑和抑郁障碍的并发症而发展的风险的新信息，关于人格特征对寻求治疗的影响的新知识，以及更详细地了解正常人格特征和焦虑和抑郁障碍之间的病因关系。这一结果将对预防和其他公共卫生努力产生影响。首席调查员的研究职业发展将通过对纵向和孪生数据进行指导分析以及相关课程工作的受保护时间而得到极大的加强。他将由才华横溢的导师指导，包括杰拉尔德·内斯塔特博士、肯尼斯·肯德勒博士、威廉·伊顿博士、梁功义博士、保罗·科斯塔博士、默里·斯坦博士、帕特里克·沙利文博士和林登·伊夫斯博士。