Clinical Research Using Non-Fourier 3D Cardiac MRI

使用非傅立叶 3D 心脏 MRI 的临床研究

• 批准号: 6730537
• 负责人: FRANK RYBICKI
• 金额: $ 17.64万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6730537
• 关键词: bioimaging /biomedical imaging; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; clinical research; clinical trials; computer program /software; coronary disorder; diagnosis design /evaluation; heart; human subject; human therapy evaluation; image enhancement; magnetic resonance imaging; myocardium; patient oriented research; single photon emission computed tomography; technology /technique development

DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is for the candidate to become a productive, independent patient-oriented investigator. This proposal details a five-year multidisciplinary career development program of patient-oriented investigation centered on cardiac magnetic resonance imaging (MRI). The health relatedness of the proposal is the clinical implementation of new imaging methods that will surmount current deficiencies in cardiac MRI methods; specifically, image artifacts and low signal to noise ratio. Therefore, the proposal aims to provide a more widespread application of MRI. One application of the new imaging methods is the evaluation of myocardial delayed enhancement which can be used to determine myocardial viability. Since the volume of viable myocardium is a critical factor in determining the subset of patients with ischemic heart disease who will benefit from surgery, achieving the most accurate estimate of viable myocardium is an important imaging goal. The program has three core components: coursework, clinical training, and clinical research. The proposed coursework component would be performed at the Harvard School of Public Health and is designed to provide training to include research fundamentals necessary to perform clinical trials. The proposed clinical training component would encompass all aspects of clinical cardiac MRI and would provide a unique opportunity for subspecialized clinical MRI practice. The clinical research component proposes to design, implement, and test in clinical trials innovative cardiac MRI methods. Three new imaging strategies are described, as are the potential advantages and disadvantages of each. These strategies will achieve the goal of minimizing image artifacts and maximizing cardiac MRI signal, and one strategy will be optimized for the three-dimensional assessment of myocardial delayed enhancement. The proposed research career development award would be performed in an environment particularly supportive of young patient-oriented investigators. Under the supervision of the experienced mentor and co-mentors, the candidate would have a unique career development opportunity that utilizes the extensive educational, clinical, and research resources of the supporting institution.

描述（由申请人提供）： 该提案的广泛，长期目标是使候选人成为一个富有成效的，独立的以患者为导向的研究者。该提案详细介绍了以心脏磁共振成像（MRI）为中心的以患者为导向的调查的五年多学科职业发展计划。该提案的健康相关性是新成像方法的临床实施，该方法将克服心脏MRI方法的当前缺陷;特别是图像伪影和低信噪比。因此，该提案旨在为MRI提供更广泛的应用。新成像方法的一个应用是评价心肌延迟增强，其可用于确定心肌存活性。由于存活心肌的体积是确定缺血性心脏病患者将受益于手术的子集的关键因素，因此实现最准确的存活心肌估计是重要的成像目标。该计划有三个核心组成部分：课程，临床培训和临床研究。拟议的课程部分将在哈佛公共卫生学院进行，旨在提供培训，包括进行临床试验所需的研究基础知识。拟议的临床培训部分将涵盖临床心脏MRI的各个方面，并将为亚专业临床MRI实践提供独特的机会。临床研究部分建议在临床试验中设计，实施和测试创新的心脏MRI方法。三个新的成像策略进行了描述，是每个潜在的优点和缺点。这些策略将实现最小化图像伪影和最大化心脏MRI信号的目标，其中一个策略将被优化用于心肌延迟增强的三维评估。拟议的研究职业发展奖将在一个特别支持年轻的以病人为导向的研究人员的环境中进行。在经验丰富的导师和共同导师的监督下，候选人将有一个独特的职业发展机会，利用支持机构广泛的教育，临床和研究资源。