Clinical Research Using Non-Fourier 3D Cardiac MRI

使用非傅立叶 3D 心脏 MRI 的临床研究

• 批准号: 6875126
• 负责人: FRANK RYBICKI
• 金额: $ 17.67万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6875126
• 关键词: bioimaging /biomedical imaging; cardiovascular disorder diagnosis; cardiovascular imaging /visualization; clinical research; clinical trials; computer program /software; coronary disorder; diagnosis design /evaluation; heart; human subject; human therapy evaluation; image enhancement; magnetic resonance imaging; myocardium; patient oriented research; single photon emission computed tomography; technology /technique development

DESCRIPTION (provided by applicant): The broad, long-term objective of this proposal is for the candidate to become a productive, independent patient-oriented investigator. This proposal details a five-year multidisciplinary career development program of patient-oriented investigation centered on cardiac magnetic resonance imaging (MRI). The health relatedness of the proposal is the clinical implementation of new imaging methods that will surmount current deficiencies in cardiac MRI methods; specifically, image artifacts and low signal to noise ratio. Therefore, the proposal aims to provide a more widespread application of MRI. One application of the new imaging methods is the evaluation of myocardial delayed enhancement which can be used to determine myocardial viability. Since the volume of viable myocardium is a critical factor in determining the subset of patients with ischemic heart disease who will benefit from surgery, achieving the most accurate estimate of viable myocardium is an important imaging goal. The program has three core components: coursework, clinical training, and clinical research. The proposed coursework component would be performed at the Harvard School of Public Health and is designed to provide training to include research fundamentals necessary to perform clinical trials. The proposed clinical training component would encompass all aspects of clinical cardiac MRI and would provide a unique opportunity for subspecialized clinical MRI practice. The clinical research component proposes to design, implement, and test in clinical trials innovative cardiac MRI methods. Three new imaging strategies are described, as are the potential advantages and disadvantages of each. These strategies will achieve the goal of minimizing image artifacts and maximizing cardiac MRI signal, and one strategy will be optimized for the three-dimensional assessment of myocardial delayed enhancement. The proposed research career development award would be performed in an environment particularly supportive of young patient-oriented investigators. Under the supervision of the experienced mentor and co-mentors, the candidate would have a unique career development opportunity that utilizes the extensive educational, clinical, and research resources of the supporting institution.

描述(由申请人提供)： 这项提议的广泛和长期目标是让候选人成为一名富有成效的、独立的、以患者为导向的研究人员。这份提案详细介绍了以心脏磁共振成像(MRI)为中心的以患者为中心的五年多学科职业发展计划。该提案与健康相关的是在临床上实施新的成像方法，这些方法将克服目前心脏MRI方法中的不足，特别是图像伪影和低信噪比。因此，该提案旨在为MRI提供更广泛的应用。新的成像方法的一个应用是评估心肌延迟增强，这可以用来确定心肌存活。由于存活心肌的体积是决定哪些缺血性心脏病患者将从手术中受益的关键因素，因此实现对存活心肌的最准确估计是一个重要的成像目标。该计划有三个核心组成部分：课程、临床培训和临床研究。拟议的课程部分将在哈佛大学公共卫生学院进行，旨在提供培训，以包括进行临床试验所需的研究基础。拟议的临床培训部分将涵盖临床心脏磁共振成像的所有方面，并将为次级临床磁共振成像实践提供独特的机会。临床研究部分建议设计、实施和在临床试验中测试创新的心脏磁共振方法。描述了三种新的成像策略，以及每种策略的潜在优点和缺点。这些策略将达到最小化图像伪影和最大化心脏MRI信号的目标，其中一个策略将针对心肌延迟增强的三维评估进行优化。拟议的研究职业发展奖将在一个特别支持以病人为导向的年轻调查人员的环境中进行。在经验丰富的导师和共同导师的监督下，应聘者将有一个独特的职业发展机会，利用支持机构广泛的教育、临床和研究资源。