CARDIOVASCULAR RISK FACTORS--CHRONIC RENAL INSUFFICIENCY

心血管危险因素——慢性肾功能不全

• 批准号: 6784606
• 负责人: MARK J SARNAK
• 金额: $ 11.67万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784606
• 关键词: acute phase protein; blood lipoprotein; cardiovascular disorder; chronic renal failure; clinical research; comorbidity; disease /disorder proneness /risk; glomerular filtration rate; homocysteine; human subject; longitudinal human study; pathologic process; uremias

DESCRIPTION (adapted from the application) Chronic renal disease is a major public health problem in the US. Cardiovascular disease (CVD) is the leading cause of morbidity and mortality. Prevention of CVD in chronic renal disease requires early intervention, during the stage of chronic renal insufficiency (CRI). The general hypothesis for the proposed research program is that the progression of CVD and chronic renal disease share common mechanisms; and that "traditional" and "uremia-related" risk factors, in particular total plasma homocysteine (tHcy), lipoprotein(a) (Lp(a)) and C-reactive protein (CRP), contribute to the progression of both CVD and chronic renal disease. The Principal Investigator (PI) has designed a rigorous training program that will provide him with the necessary-skills, experience and opportunities to develop into an independent investigator in the field of cardiovascular epidemiology in chronic renal disease. He will obtain a Master's of Science in Clinical Care Research, participate in projects utilizing a broad range of study designs for clinical care research, and carry out an original research project from its inception to completion. His mentors have extensive experience in clinical investigation in nephrology, CVD epidemiology and clinical care research methodology. There are currently minimal data available on the incidence of CVD or the risk factors for CVD in CRI. The Modification of Diet in Renal Disease (MDRD) Study was the largest prospective study of patients with CRI, and is an ideal study population for the proposed research. Specific aims are as follows: 1. Measure tHcy, Lp(a), apo(a) isoforms and CRP levels from frozen samples taken at baseline in the MDRD Study and characterize the distribution of levels and their relationship to baseline glomerular filtration rate (GFR) and other factors. 2. Determine whether baseline levels of tHcy, Lp(a), apo(a) isoforms or CRP are predictors of subsequent GFR decline. 3. Resume contact with the MDRD Study cohort, collect data on CVD and renal outcomes, and determine the relationship of traditional and uremia-related risk factors to CVD and renal outcomes. Statistical analysis reveals adequate power to evaluate each aim and a pilot study has documented the feasibility of aim 3. The PI has assembled a team of nephrologists, CVD epidemiologists, and nutrition scientists to assist him in the conduct of the project; enlisted the collaboration of the MDRD Study Data Coordinating Center, and organized internal and external advisory committees to monitor his progress. The proposed L training program and research project will prepare him for a career as an independent investigator.

描述（改编自应用程序）

项目成果

Uric acid and long-term outcomes in CKD.

• DOI: 10.1053/j.ajkd.2008.12.021
• 发表时间: 2009-05
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Madero M;Sarnak MJ;Wang X;Greene T;Beck GJ;Kusek JW;Collins AJ;Levey AS;Menon V
• 通讯作者: Menon V

Homocysteine in chronic kidney disease: Effect of low protein diet and repletion with B vitamins.

• DOI: 10.1111/j.1523-1755.2005.00234.x
• 发表时间: 2005-04
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: V. Menon;Xuelei Wang;T. Greene;G. Beck;J. Kusek;J. Selhub;A. Levey;M. Sarnak

Factors associated with lipoprotein(a) in chronic kidney disease.

慢性肾脏病中与脂蛋白（a）相关的因素。

• DOI: 10.1053/j.ajkd.2004.08.043
• 发表时间: 2005
• 期刊: American journal of kidney diseases : the official journal of the National Kidney Foundation
• 作者: Uhlig,Katrin;Wang,Shin-Ru;Beck,GeraldJ;Kusek,JohnW;Marcovina,SanticaM;Greene,Tom;Levey,AndrewS;Sarnak,MarkJ
• 通讯作者: Sarnak,MarkJ

Asymmetric dimethylarginine and mortality in stages 3 to 4 chronic kidney disease.

不对称二甲基精氨酸和 3 至 4 期慢性肾病的死亡率。

• DOI: 10.2215/cjn.06671208
• 发表时间: 2009
• 期刊: Clinical journal of the American Society of Nephrology : CJASN
• 作者: Young,JillMelendez;Terrin,Norma;Wang,Xuelei;Greene,Tom;Beck,GeraldJ;Kusek,JohnW;Collins,AllanJ;Sarnak,MarkJ;Menon,Vandana
• 通讯作者: Menon,Vandana

Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts.

• DOI: 10.1038/ki.2010.550
• 发表时间: 2011-06
• 期刊: Kidney international
• 影响因子: 19.6
• 作者: Astor BC;Matsushita K;Gansevoort RT;van der Velde M;Woodward M;Levey AS;Jong PE;Coresh J;Chronic Kidney Disease Prognosis Consortium;Astor BC;Matsushita K;Gansevoort RT;van der Velde M;Woodward M;Levey AS;de Jong PE;Coresh J;El-Nahas M;Eckardt KU;Kasiske BL;Wright J;Appel L;Greene T;Levin A;Djurdjev O;Wheeler DC;Landray MJ;Townend JN;Emberson J;Clark LE;Macleod A;Marks A;Ali T;Fluck N;Prescott G;Smith DH;Weinstein JR;Johnson ES;Thorp ML;Wetzels JF;Blankestijn PJ;van Zuilen AD;Menon V;Sarnak M;Beck G;Kronenberg F;Kollerits B;Froissart M;Stengel B;Metzger M;Remuzzi G;Ruggenenti P;Perna A;Heerspink HJ;Brenner B;de Zeeuw D;Rossing P;Parving HH;Auguste P;Veldhuis K;Wang Y;Camarata L;Thomas B;Manley T
• 通讯作者: Manley T