IMMUNOBIOLOGY OF AGING

我们计划的长期目标是纠正与年龄相关的 导致人类疾病的免疫功能的变化。冲向 为此，该方案汇集了三个相互关联的项目，以 稳定的B细胞自发出现的机制研究 和/或T细胞克隆性扩增随年龄增长。首先，一个人的角色 与年龄相关的淋巴系统的多样性降低 克隆性淋巴细胞扩增的出现将被研究。在……里面 此外，抗原刺激和/或受损克隆的作用 动态平衡在克隆淋巴细胞群体中的持久性将是 检查过了。一个关键问题是确定克隆的存在是否存在 淋巴细胞是老年小鼠免疫功能受损的原因之一。 也就是说，通过减少与年龄相关的淋巴克隆扩张 淋巴系统的多样性或通过生产 特定的细胞因子，有助于免疫衰老。的功能 老年小鼠中自发出现的T细胞克隆将与 来自中国的转基因抗流感T细胞克隆 出生。抗流感T细胞克隆对免疫功能的影响 对幼龄和老年小鼠的系统以及抗衰老作用的研究 将研究小鼠和老年小鼠的流感TCRT细胞克隆。

The long range goal of our program is to correct the age-associated changes in immune function that contribute to human disease. Toward this end, this program brings together three inter-related projects to study the mechanisms underlying the spontaneous appearance of stable B and/or T cell clonal expansions with age. First of all, the role of age-associated decreased diversity of the lymphoid repertoire to the appearance of clonal lymphocyte expansions will be studied. IN addition, the role of antigen stimulation and/or impaired clonal homeostasis in the persistence of clonal lymphocyte populations will be examined. A key question is to determine whether the presence of clonal lymphocytes contribute to the impaired immune function seen in old mice. That is, do to age-associated lymphoid clonal expansions, by decreasing the diversity of the lymphoid repertoire or by the production of specific cytokines, contribute to immune senescence. The function of spontaneously-appearing T cell clones in old mice will be compared to that of transgenic anti-influenza T cell clones which are present from birth. The influence of anti-influenza T cell clones on the immune system of young and old mice as well as the function of the anti- influenza TCR T cell clone in young and old mice will be studied.