Sugar Addiction in Rats: Links to Drugs of Abuse

老鼠的糖瘾：与滥用药物的联系

• 批准号: 6645078
• 负责人: NICOLE M AVENA
• 金额: $ 3.98万
• 依托单位: PRINCETON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645078
• 关键词: acetylcholine; alcoholic beverage consumption; amphetamines; behavioral /social science research tag; behavioral habituation /sensitization; body weight; craving; dietary carbohydrates; dietary lipid; dopamine; drug addiction; laboratory rat; microdialysis; neurochemistry; neuropsychology; nucleus accumbens; nutrition related tag; obesity; operant conditionings; overeating; predoctoral investigator; pregnancy

DESCRIPTION (provided by applicant): The objectives and aims of this research proposal are to investigate the neural and behavioral correlates of sugar and drug addictions. The recent increased awareness of eating disorders and obesity in our country has led many to speculate about the addictive properties of food, and how this addiction may be related to the over-eating epidemic our society is currently facing. Recent research in rodents has indicated that sugar bingeing can lead to dependency that shares some behavioral and neurochemical similarities with drug dependency (Colantuoni et al., 2001; Colantuoni et al., 2002). This proposal plans to elaborate on these findings, by behaviorally investigating sugar craving, sensitization and cross-sensitization with other known drugs of abuse. Moreover, this research will examine neurochemical similarities between sugar and drug addiction in the nucleus accumbens. By further elucidating a possible link between food and drugs, new pharmacological and behavioral treatments may be developed to treat eating disorders.

描述（由申请人提供）：