Translational Research on Addiction to Palatable Food

美味食物成瘾的转化研究

• 批准号: 8656088
• 负责人: NICOLE M AVENA
• 金额: $ 16.8万
• 依托单位: ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-05-15 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8656088
• 关键词: Accounting; Address; Affect; Animal Model; Animals; Area; Award; Behavior; Behavioral; Binge Eating; Binge eating disorder; Biological; Brain; CREB1 gene; Canned Foods; Clinical; Clinical Research; Clinical Sciences; Complement; Control Groups; DSM-IV; Data; Dependence; Dependency; Detection; Development; Development Plans; Diagnosis; Diet; Disease; Doctor of Philosophy; Drug Addiction; Eating; Eating Disorders; Educational process of instructing; Elements; Epidemiology; Exhibits; Fatty acid glycerol esters; Feeding behaviors; Florida; Food; Food Preferences; Foundations; Funding; Future; Galanin; Gene Expression; General Population; Genes; Goals; Health; Hyperphagia; Hypothalamic structure; Incidence; Individual; Intake; Knowledge; Laboratory Research; Lead; Measures; Medicine; Mentors; Methods; Modeling; Molecular; Molecular Biology; Motivation; National Research Service Awards; Nature; Neurobiology; Neuropeptides; Neurosciences; Nucleus Accumbens; Nutrient; Obesity; Opiates; Overweight; Patients; Phase; Population; Pre-Clinical Model; Proteins; Psychiatry; Psychology; Psychometrics; Publications; Rattus; Reporting; Research; Research Personnel; Research Project Grants; Research Training; Resources; Rewards; Rodent Model; Role; Scientist; Series; Substance Addiction; Sucrose; System; Techniques; Testing; Training; Training and Education; Translational Research; United States National Institutes of Health; Universities; Validity and Reliability; Weight; Withdrawal; addiction; base; behavior measurement; career; career development; college; design; experience; feeding; food addiction; interest; lectures; meetings; neural circuit; neurochemistry; novel; overexpression; pre-clinical; pre-clinical research; pre-doctoral; preclinical study; prevent; professor; programs; research and development; research study; response; responsible research conduct; scientific organization; skills; statistics; sugar; theories; tool; translational approach; trend

DESCRIPTION (provided by applicant): With obesity rates continuing to rise, new and different research approaches are needed to develop strategies to impede this trend. I have been using preclinical models to study the unique theory that overeating of palatable foods, in the form of binge eating, can resemble an "addiction" to food, with concomitant behaviors and neurochemical changes that are like those seen with drug addiction. These data and the findings of others support the theory that overeating of palatable food might produce an extreme motivation that resembles a dependency on certain foods, possibly fueling the urge to overeat and subsequent obesity in some individuals. As it is imperative to test whether animal models of overeating are clinically reliable, in this proposal I plan to obtain clinical research training so that I can study and refine psychometric methods to assess "food addiction" in clinical patients who are obese or have binge eating disorder. Further, I plan to take the next step in my preclinical research by obtaining data on the effect that overeating can have on the expression of genes that are known to have roles in addiction, and to understand how overeating on different types of nutrients (i.e., fat vs. sugar) can affect related brain systems and subsequent behavior. I have an aggregate skill set that will be further developed in this proposal, which will enable me to complete these studies and facilitate my development as an independent research scientist. I have a Ph.D. in Psychology and Neuroscience from Princeton University and postdoctoral experience in molecular biology from The Rockefeller University. I am now Assistant Research Professor at University of Florida, College of Medicine, Department of Psychiatry. My research studies up to this point have focused on using my skills in behavioral neuroscience and molecular biology to study of "food addiction," in part, through the use of an animal model of sugar dependence that I developed in my Ph.D. research. This research has resulted in 33 publications, many speaking invitations and presentations, and several awards. Further, I have a track record of obtaining funding through individual predoctoral and postdoctoral NIH NRSA awards, and small private foundations. Recognizing the importance and usefulness of translational research, I now plan to expand my research skills by obtaining additional training in clinical science. This will allow me to relate my preclinical studies of overeating to clinical populations, and this will help to provide further validity to the theory of "food addiction." This proposal outlines a series of career development activities that will be conducted within the context of translational research on overeating palatable foods and the possible ensuing development of "food addiction." The research and career development activities will occur at the University of Florida, College of Medicine, Department of Psychiatry, which is an ideal place for this training to take place. Not only are there several researchers in the Addition Medicine division of the Department of Psychiatry who are interested in studying "natural addictions," but there are also resources and individuals throughout the University of Florida that will be an asset to this research project and my development as an independent scientist. A team of mentors has been assembled to guide me through this development phase, each with a unique contribution to the proposed training and research elements. In addition, I have identified collaborators that will contribute their expertise and knowledge to the proposed experiments. Career development plans include advanced coursework in clinical research, epidemiology and statistics, as well as participation in scientific organizations, attendance to lectures and seminars, and training in the responsible conduct of research. The research training will focus on developing my skills as a clinical researcher so I can conduct translational research on overeating and abnormal food intake. In the long term, I hope to have my own teaching and research laboratory in which I can continue to conduct research on the neurobiology of aberrant feeding behavior using both preclinical and clinical models. The proposed experiments are centered on developing a translational line of inquiry. Aim 1 will employ clinical research practices and psychometrics to modify and implement the Yale Food Addiction Scale in obese and binge eating disorder patients and normal controls to 1) determine if patients in these clinical populations show signs of "food addiction" using this scale, and 2) relate food preference to the addiction-like behaviors using newly-developed subscales. Further, to inform and expand on these findings, Aim 2 is a preclinical research component that will assess differences in behaviors and gene expression in reward-related brain areas that result from overeating fat vs. sugar using established animal models. Aim 2 will use behavioral measures and molecular biological techniques in rodent models of overeating. This translational approach to research will permit a better understanding of various aspects of overeating and inform the development of future models to investigate the biological basis of aberrant feeding behavior, which may then be applied to studies in clinical populations. At the end of this training, I will be able to launch a career as an independent investigator and be poised to develop a comprehensive, programmatic translational research program.

描述（由申请人提供）：随着肥胖率不断上升，需要采用新的和不同的研究方法来制定阻碍这种趋势的策略。我一直在使用临床前模型来研究独特的理论，即以暴饮暴食的形式暴饮暴食的食物对食物的“成瘾”类似，具有伴随的行为和神经化学的变化，就像被吸毒所看到的那样。这些数据和其他人的发现支持以下理论：暴饮暴食可能会产生极端的动力，类似于对某些食物的依赖，从而激发了某些人暴饮暴食和随后的肥胖症的冲动。由于必须测试暴饮暴食模型是否在临床上可靠，因此在此提案中，我计划获得临床研究培训，以便我可以研究和完善心理测量方法来评估肥胖或患有暴饮暴食障碍的临床患者的“食物成瘾”。此外，我计划通过获取暴饮暴食对众所周知在成瘾中具有作用的基因表达的影响的数据来迈出下一步，并了解如何在不同类型的营养物质（即脂肪与糖与糖）上过度食用如何影响相关的大脑系统和后续行为。我有一个总体技能，该提案将进一步发展，这将使我能够完成这些研究并促进我作为独立研究科学家的发展。我有博士学位普林斯顿大学的心理学和神经科学博士学位以及洛克菲勒大学分子生物学的博士后经验。我现在是佛罗里达大学医学院精神病学系的助理研究教授。到目前为止，我的研究一直集中在使用我在博士学位中开发的糖依赖性动物模型的部分来利用我在行为神经科学和分子生物学方面的技能来研究“食物成瘾”。研究。这项研究导致了33个出版物，许多讲话的邀请和演讲以及几个奖项。此外，我还有一个记录记录，即通过单独的毒品和博士后NIH NRSA奖和小型私人基金会获得资金。认识到翻译研究的重要性和实用性，我现在计划通过获得临床科学的其他培训来扩大研究技能。这将使我能够将暴饮暴食的临床前研究与临床人群联系起来，这将有助于为“食物成瘾”理论提供进一步的有效性。该提案概述了一系列职业发展活动，这些活动将在转化研究中，关于暴饮暴食的食物以及随之而来的“食物成瘾”的发展。研究和职业发展活动将在佛罗里达大学，医学院，精神病学系进行，这是进行该培训的理想场所。精神病学系的加法医学部不仅有几位研究人员有兴趣研究“自然成瘾”，而且佛罗里达大学的整个资源和个人也将成为该研究项目的资产，而我作为独立科学家的发展。一组导师团队被组装为指导我进入这个发展阶段，每个阶段都为拟议的培训和研究元素做出了独特的贡献。此外，我还确定了合作者，他们将为拟议的实验贡献其专业知识和知识。职业发展计划包括临床研究，流行病学和统计学的高级课程，以及参与科学组织，参加讲座和研讨会的出席以及负责任的研究进行培训。研究培训将着重于发展我作为临床研究人员的技能，因此我可以就食物暴饮暴食和异常食物进行转化研究。从长远来看，我希望拥有自己的教学和研究实验室，在这些实验室中，我可以继续使用临床前和临床模型对异常喂养行为的神经生物学进行研究。所提出的实验集中在开发转化的查询线上。 AIM 1将采用临床研究实践和精神计量学来修改和实施肥胖和暴饮暴食障碍患者的耶鲁食品成瘾量表，以及正常对照对1）确定这些临床人群中的患者是否使用这种量表显示了“食物成瘾”的迹象，以及2）使用新近开发的子群体将食物偏好与成瘾行为相关联。此外，为了告知和扩展这些发现，AIM 2是一个临床前研究组成部分，它将评估与奖励相关的大脑区域的行为和基因表达的差异，这是由于使用已建立的动物模型暴饮超过脂肪与糖导致的奖励。 AIM 2将在暴饮暴食模型中使用行为措施和分子生物技术。这种翻译方法将使对暴饮暴食的各个方面更好地理解未来模型的发展，以研究异常喂养行为的生物学基础，然后可以将其应用于临床人群的研究。在这次培训结束时，我将能够从事独立调查员的职业，并准备制定一项全面的，程序化的翻译研究计划。