Developing new metal-based complexes for 18F-based radiopharmaceutical (PET) imaging applications

开发用于 18F 放射性药物 (PET) 成像应用的新型金属配合物

• 批准号: 2284648
• 金额: --
• 依托单位: University of Southampton
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2284648
• 关键词: Developing; new; metal; based; complexes

The project focusses on development of new metal complexes for radiofluorination for potential applications as next generation medical imaging agents via positron emission tomography (PET) - a very widely used medical imaging technique used in hospitals and clinics for detection of diseases such as cancers.This project is at the synthetic chemistry/radiochemistry interface and the successful applicant will have the opportunity to develop metal fluoride complexes with macrocyclic co-ligands as possible PET tracer candidates, as well as to use the GE facilities at St Thomas' Hospital (London) to develop efficient methods for their radiofluorination (using the fluorine-18 isotope), purification and stability testing.

该项目重点开发用于放射性氟化的新型金属配合物，通过正电子发射断层扫描（PET）作为下一代医学成像剂的潜在应用，PET是一种在医院和诊所广泛使用的医学成像技术，用于检测癌症等疾病。该项目处于合成化学/放射化学界面，成功的申请人将有机会开发具有大环的金属氟化物配合物 联合配体作为可能的 PET 示踪剂候选物，并使用圣托马斯医院（伦敦）的 GE 设施开发有效的放射性氟化（使用氟 18 同位素）、纯化和稳定性测试方法。