Patellofemoral Osteoarthritis Epidemiology

描述（由申请人提供）：我们目前对膝关节骨关节炎（OA）疼痛和残疾来源的了解有限。以前的研究主要集中在胫股（TF）关节，并已显示结构变化与疼痛和残疾之间的相关性较差。尽管有人认为髌股（PF）关节可能与下肢残疾密切相关，但对PF关节在膝关节OA中的评估为膝关节疼痛提供了更清晰的解释，但对PF关节的关注相对较少。虽然TF OA有良好的信息，但髌股OA的流行病学仍不清楚。此外，目前的数据表明，与疾病相关的风险因素是不同的PF OA和TF OA。可能是PF关节特有的风险因素的影响尚不清楚，包括股四头肌力量、腘绳肌股四头肌不平衡、肌肉质量、髌骨对线不良和股骨长度与PF OA的关系。该项目将利用从一项大规模纵向研究中收集的数据，该研究包括对膝关节疼痛和残疾的广泛评估以及对参与者进行的系列膝关节MRI和X光检查;以解决一个总体特定目标。使用纵向数据（包括系列MRI）探索PF软骨损失和PF OA的风险因素。在这个项目中，我们将评估PF软骨损失和与症状相关的相同PF软骨损失的发展。

DESCRIPTION (provided by applicant): Our current understanding of the sources of pain and hence disability in knee osteoarthritis (OA) is limited. Previous research has concentrated primarily on tibiofemoral (TF) joints and has shown a poor correlation between structural change and both pain and disability. Relatively little heed has been paid to the patellofemoral (PF) joint, despite suggestions that it may be strongly correlated with lower extremity disability, and that assessment of the PF joint in knee OA provides a clearer explanation for knee pain. Whilst good information is available for TF OA, the epidemiology of patellofemoral OA remains unclear. Moreover current data suggest that the risk factors associated with disease are different for PF OA and TF OA. The contribution of risk factors likely unique to the PF joint including the relationship of quadriceps strength, hamstring quadriceps muscle imbalance, muscle mass, patella malalignment and femur length to PF OA is unknown. This project will take advantage of already collected data from a large-scale longitudinal study that incorporates extensive evaluations of knee pain and disability and serial knee MRI's and x-rays on participants; to address one overall specific aim. Using longitudinal data (including serial MRI) to explore PF cartilage loss, and risk factors for PF OA. In this project we will evaluate PF cartilage loss and development of this same PF cartilage loss associated with symptoms.