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Patellofemoral Osteoarthritis Epidemiology

髌股骨关节炎流行病学

基本信息

批准号：
7064229
负责人：
DAVID J HUNTER
金额：
$ 7.89万
依托单位：
BOSTON UNIVERSITY MEDICAL CAMPUS
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-06-01 至 2007-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7064229
关键词：
X ray age difference body composition cartilage clinical research disease /disorder proneness /risk epidemiology femur gender difference human data knee longitudinal human study magnetic resonance imaging obesity osteoarthritis pain

项目摘要

DESCRIPTION (provided by applicant): Our current understanding of the sources of pain and hence disability in knee osteoarthritis (OA) is limited. Previous research has concentrated primarily on tibiofemoral (TF) joints and has shown a poor correlation between structural change and both pain and disability. Relatively little heed has been paid to the patellofemoral (PF) joint, despite suggestions that it may be strongly correlated with lower extremity disability, and that assessment of the PF joint in knee OA provides a clearer explanation for knee pain. Whilst good information is available for TF OA, the epidemiology of patellofemoral OA remains unclear. Moreover current data suggest that the risk factors associated with disease are different for PF OA and TF OA. The contribution of risk factors likely unique to the PF joint including the relationship of quadriceps strength, hamstring quadriceps muscle imbalance, muscle mass, patella malalignment and femur length to PF OA is unknown. This project will take advantage of already collected data from a large-scale longitudinal study that incorporates extensive evaluations of knee pain and disability and serial knee MRI's and x-rays on participants; to address one overall specific aim. Using longitudinal data (including serial MRI) to explore PF cartilage loss, and risk factors for PF OA. In this project we will evaluate PF cartilage loss and development of this same PF cartilage loss associated with symptoms.

描述(由申请人提供)：我们目前对膝骨性关节炎(OA)疼痛的来源以及残疾的了解是有限的。以前的研究主要集中在胫股关节(TF)，显示结构变化与疼痛和残疾之间的相关性较差。相对较少注意到的是髌股关节(PF)，尽管有建议认为它可能与下肢残疾密切相关，而且在膝关节骨性关节炎中对PF关节的评估为膝关节疼痛提供了一个更清晰的解释。虽然有关于TFOA的良好信息，但膝骨股骨骨关节炎的流行病学仍不清楚。此外，目前的数据表明，与疾病相关的危险因素在PF和TFOA中是不同的。可能是PF关节特有的危险因素，包括股四头肌力量、腿肌股四头肌肌肉失衡、肌肉质量、髌骨排列不良和股骨长度对PF OA的影响尚不清楚。该项目将利用已经从一项大规模纵向研究中收集的数据，该研究包括对膝关节疼痛和残疾的广泛评估以及对参与者进行的一系列膝关节核磁共振和X光检查；以解决一个总体的具体目标。使用纵向数据(包括系列MRI)来探讨PF软骨丢失，以及PF OA的危险因素。在这个项目中，我们将评估PF软骨的丢失和发展与此相同的PF软骨丢失的症状。