Diet and Cancer in Puerto Rican Men

波多黎各男性的饮食与癌症

• 批准号: 6788735
• 负责人: JO L. FREUDENHEIM
• 金额: $ 7.85万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2007-08-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6788735
• 关键词: Leguminoseae; Puerto Rican; cancer registry /resource; cancer risk; clinical research; diet; human data; male; neoplasm /cancer epidemiology; nutrition related neoplasm /cancer; prostate neoplasms

DESCRIPTION (provided by applicant): This is a small grant to study prospectively diet and prostate cancer among Puerto Rican men who took part in the Puerto Rico Heart Health Program (PRHHP). Few studies have been able to study the relationship of diet with prostate cancer mortality longitudinally among Hispanics or any other minority group in the United States. Although cancer mortality rates have decreased in the past 20 years in the general population, it has increased in the Hispanic population. Cancer mortality rates among Hispanics are lower than those observed among non-Hispanic whites; however, for Puerto Ricans both in the United States and in Puerto Rico, cancer mortality rates are greater than those observed for all Hispanics combined. Moreover, the number one cancer killer among Puerto Rican men is prostate cancer, not lung cancer. The reason for this inter- and intra-ethnic variation in cancer rates remains unclear. Established and emerging risk factors associated with prostate cancer include age, race, diet, obesity, physical inactivity, smoking, alcohol intake and sexually transmitted diseases, among others. The PRHHP collected information on these risk factors during four examinations between 1964 and 1980 with enormous potential for increasing our understanding of the etiology of this disease in US minority population. Most of the published information on legumes and prostate cancer are based on findings from soy legumes with limited applicability to the US diet, since non-soy legumes are the most commonly eaten type of legumes in the Western diet. We found only one published epidemiological study that examined the relationship of non-soy legumes with prostate cancer. Consumption per capita of legumes in Puerto Rico is double that of the US. The specific aim of this small grant is to examine the relationship of dietary consumption of non-soy legumes with prostate cancer mortality in Puerto Rican men. For this grant we plan to ascertain and characterize prostate cancer mortality in the cohort of men from the PRHHP using information from the Puerto Rico Demographic Registry, Puerto Rico Cancer Registry and the National Death Index Plus. This application is innovative because (a) it takes advantage of an established cohort to investigate cancer mortality in an under-studied Hispanic subgroup with higher cancer mortality rates than other Hispanic subgroups; (b) has the potential to study other exposures such as skin color, sexually transmitted disease, alcohol, smoking and other emerging risk factors with prostate and other cancers; and (c) will contribute new knowledge regarding the relationship between intake of non-soy legumes and prostate cancer mortality.

描述（由申请人提供）： 这是一笔小额赠款，用于对参加波多黎各心脏健康计划 (PRHHP) 的波多黎各男性进行前瞻性饮食和前列腺癌研究。很少有研究能够纵向研究美国西班牙裔或任何其他少数群体的饮食与前列腺癌死亡率的关系。尽管过去 20 年来，普通人群的癌症死亡率有所下降，但西班牙裔人群的癌症死亡率却有所上升。西班牙裔的癌症死亡率低于非西班牙裔白人；然而，对于美国和波多黎各的波多黎各人来说，癌症死亡率高于所有西班牙裔人的癌症死亡率总和。此外，波多黎各男性的头号癌症杀手是前列腺癌，而不是肺癌。种族间和种族内癌症发病率差异的原因尚不清楚。与前列腺癌相关的既定和新出现的危险因素包括年龄、种族、饮食、肥胖、缺乏身体活动、吸烟、饮酒和性传播疾病等。 PRHHP 在 1964 年至 1980 年间的四次检查中收集了有关这些危险因素的信息，这对于增进我们对美国少数族裔中这种疾病的病因学的了解具有巨大的潜力。 大多数已发表的有关豆类和前列腺癌的信息都是基于大豆豆类的研究结果，对美国饮食的适用性有限，因为非大豆豆类是西方饮食中最常食用的豆类类型。我们只发现一项已发表的流行病学研究检查了非大豆豆类与前列腺癌的关系。波多黎各的人均豆类消费量是美国的两倍。这笔小额赠款的具体目的是研究波多黎各男性的非大豆豆类饮食消费与前列腺癌死亡率的关系。 对于这笔赠款，我们计划使用来自波多黎各人口登记处、波多黎各癌症登记处和国家死亡指数附加版的信息来确定和描述来自 PRHHP 的男性队列中的前列腺癌死亡率。该应用程序具有创新性，因为 (a) 它利用已建立的队列来调查未充分研究的西班牙裔亚群的癌症死亡率，该亚群的癌症死亡率高于其他西班牙裔亚群； (b) 具有研究其他暴露的潜力，例如肤色、性传播疾病、酒精、吸烟以及其他新出现的前列腺癌和其他癌症的危险因素； (c) 将提供有关非大豆豆类摄入量与前列腺癌死亡率之间关系的新知识。