ENVIRONMENTAL AND GENETIC DETERMINANTS OF BREAST CANCER

这里提出的是一项研究的作用，总的多氯联苯，个别多氯联苯 同系物、滴滴涕和灭蚁灵在绝经后乳腺癌病因学中的作用。 将评价这些环境污染物的血清水平。在 此外，酶的遗传多态性与风险的关联 参与致癌物质代谢和解毒（细胞色素P450 酶CYP 2D 6和CYP 1A 1，以及谷胱甘肽-S-转移酶）将被 考察最后，修改关联的效果， 具有遗传多态性风险的环境污染物将被 评估。 本研究将使用储存的冷冻（-70 ℃）血液标本 作为一个更大的病例对照研究的一部分收集的饮食，生殖和 绝经后乳腺癌的其他风险因素。150例患者 原发性，组织学证实的疾病。群体对照（n= 150） 将根据年龄、抽血日期和频率与病例匹配 与家庭以外的其他乳腺癌风险因素病例相匹配 有乳腺癌病史。将抽取新的血液样本进行DNA检测 决心。已经收集了患病前的访谈数据， 日常饮食、病史、生殖史和家族史 癌这项研究提供了一个重要的机会， 潜在的重要环境污染物的检查 结合遗传易感性和其他已知风险的评估 在美国东北部，一个地理区域， 乳腺癌

Proposed here is a study of the role of total PCBs, individual PCB congeners, DDT and mirex in the etiology of postmenopausal breast cancer. Serum levels of these environmental contaminants will be evaluated. In addition, the association with risk of genetic polymorphisms of enzymes involved in carcinogen metabolism and detoxification (the cytochrome P450 enzymes CYP2D6 and CYP1A1, and glutathione-S-transferase) will be examined. Finally, effect modification of the association of the environmental contaminants with risk by the genetic polymorphisms will be assessed. This study will use stored, frozen (-70 degrees C) blood specimens collected as part of a larger case-control study of diet, reproductive and other factors in risk of postmenopausal breast cancer. Cases (n= 150) have primary, histologically confirmed disease. Population controls (n= 150) will be matched to cases on age and date of blood draw and frequency matched to cases on other breast cancer risk factors other than family history of breast cancer. New blood samples will be drawn for the DNA determinations. Interview data have already been collected on predisease usual diet, medical history, reproductive history and family history of cancer. This study provides an important opportunity for efficient examination of potentially important environmental contaminants in conjunction with evaluation of genetic susceptibility and other known risk factors, in the northeastern U.S., a geographic region at high risk of breast cancer.