Development of lanthanide probes for the monitoring of pH and the physiological redox environment.
开发用于监测 pH 值和生理氧化还原环境的镧系元素探针。
基本信息
- 批准号:2285033
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:英国
- 项目类别:Studentship
- 财政年份:2019
- 资助国家:英国
- 起止时间:2019 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This project involves the preparation and study of a series of metal complexes that respond to changes in the biological chemistry of living systems, with a particular focus on preparing complexes that respond to the biochemical consequences of redox stress in biology. There are several conditions which affect the pH and redox environment within the body these include cancer1,2, chronic inflammation1, ischemia1 and Alzheimer's disease2. Multimodal lanthanide probes could be made to detect tissue being starved of oxygen (hypoxia) and tissue damage by reperfusion (the restoration of blood flow and, therefore, the supply of oxygen to areas to which blood flow has been restricted) as both these conditions cause the pH3 and redox environment of the cells involved to become unbalanced. Lanthanide probes are lanthanide complexes which have been tailored to respond to the chemical environment around them. Their response can be observed by magnetic resonance imaging (MRI), fluorescence imaging and many other imaging techniques. The development of multimodal probes which react to these imbalances could be used to effectively monitor and diagnose these and many other conditions by MRI and fluorescence imaging. The aim of this project is to produce multimodal lanthanide probes to monitor and detect physiological conditions by MRI, fluorescence imaging and other imaging techniques. We hope to achieve this by modifying kinetically stable lanthanide complexes by adding redox, pH, and enzyme sensitive functional groups The project explores a new methodology to achieve these goals, relying on the exploitation of a modular route to heterometallic complexes to incorporate two luminescent domains that enable changes in guest concentration to be quantified. This project falls within the EPSRC manufacturing the future, healthcare technologies and medical imaging (including medical image and vision computing) research area as it concerns the production and multimodal probes to be used for medical imaging for the diagnosis of a number of conditions and imbalances.
该项目涉及一系列金属配合物的制备和研究,这些配合物响应生命系统的生物化学变化,特别关注制备响应生物学中氧化还原应激的生物化学后果的配合物。有几种情况会影响体内的pH值和氧化还原环境,包括癌症1,2,慢性炎症1,缺血1和阿尔茨海默病2。多模式镧系元素探针可用于检测组织缺氧(缺氧)和再灌注(恢复血流,因此向血流受限的区域供应氧气)造成的组织损伤,因为这两种情况都会导致相关细胞的pH 3和氧化还原环境变得不平衡。镧系元素探针是镧系元素复合物,其已经被定制以响应它们周围的化学环境。它们的反应可以通过磁共振成像(MRI)、荧光成像和许多其他成像技术来观察。对这些不平衡做出反应的多模式探针的开发可用于通过MRI和荧光成像有效地监测和诊断这些和许多其他病症。该项目的目的是生产多模态镧系元素探针,通过MRI、荧光成像和其他成像技术监测和检测生理状况。我们希望通过添加氧化还原、pH和酶敏感官能团来修饰动力学稳定的镧系元素络合物来实现这一目标。该项目探索了一种实现这些目标的新方法,依赖于利用一种模块化路线来形成异金属络合物,以结合两个发光域,从而能够量化客体浓度的变化。该项目福尔斯属于EPSRC制造未来,医疗保健技术和医学成像(包括医学图像和视觉计算)研究领域,因为它涉及生产和多模态探头用于医学成像,用于诊断许多疾病和不平衡。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
其他文献
吉治仁志 他: "トランスジェニックマウスによるTIMP-1の線維化促進機序"最新医学. 55. 1781-1787 (2000)
Hitoshi Yoshiji 等:“转基因小鼠中 TIMP-1 的促纤维化机制”现代医学 55. 1781-1787 (2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
LiDAR Implementations for Autonomous Vehicle Applications
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
吉治仁志 他: "イラスト医学&サイエンスシリーズ血管の分子医学"羊土社(渋谷正史編). 125 (2000)
Hitoshi Yoshiji 等人:“血管医学与科学系列分子医学图解”Yodosha(涉谷正志编辑)125(2000)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Effect of manidipine hydrochloride,a calcium antagonist,on isoproterenol-induced left ventricular hypertrophy: "Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,K.,Teragaki,M.,Iwao,H.and Yoshikawa,J." Jpn Circ J. 62(1). 47-52 (1998)
钙拮抗剂盐酸马尼地平对异丙肾上腺素引起的左心室肥厚的影响:“Yoshiyama,M.,Takeuchi,K.,Kim,S.,Hanatani,A.,Omura,T.,Toda,I.,Akioka,
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('', 18)}}的其他基金
An implantable biosensor microsystem for real-time measurement of circulating biomarkers
用于实时测量循环生物标志物的植入式生物传感器微系统
- 批准号:
2901954 - 财政年份:2028
- 资助金额:
-- - 项目类别:
Studentship
Exploiting the polysaccharide breakdown capacity of the human gut microbiome to develop environmentally sustainable dishwashing solutions
利用人类肠道微生物群的多糖分解能力来开发环境可持续的洗碗解决方案
- 批准号:
2896097 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
A Robot that Swims Through Granular Materials
可以在颗粒材料中游动的机器人
- 批准号:
2780268 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Likelihood and impact of severe space weather events on the resilience of nuclear power and safeguards monitoring.
严重空间天气事件对核电和保障监督的恢复力的可能性和影响。
- 批准号:
2908918 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Proton, alpha and gamma irradiation assisted stress corrosion cracking: understanding the fuel-stainless steel interface
质子、α 和 γ 辐照辅助应力腐蚀开裂:了解燃料-不锈钢界面
- 批准号:
2908693 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Field Assisted Sintering of Nuclear Fuel Simulants
核燃料模拟物的现场辅助烧结
- 批准号:
2908917 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Assessment of new fatigue capable titanium alloys for aerospace applications
评估用于航空航天应用的新型抗疲劳钛合金
- 批准号:
2879438 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Developing a 3D printed skin model using a Dextran - Collagen hydrogel to analyse the cellular and epigenetic effects of interleukin-17 inhibitors in
使用右旋糖酐-胶原蛋白水凝胶开发 3D 打印皮肤模型,以分析白细胞介素 17 抑制剂的细胞和表观遗传效应
- 批准号:
2890513 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
Understanding the interplay between the gut microbiome, behavior and urbanisation in wild birds
了解野生鸟类肠道微生物组、行为和城市化之间的相互作用
- 批准号:
2876993 - 财政年份:2027
- 资助金额:
-- - 项目类别:
Studentship
相似海外基金
Cherenkov luminescence mediated excitation of discrete lanthanide optical probes
切伦科夫发光介导的离散镧系元素光学探针的激发
- 批准号:
10876727 - 财政年份:2023
- 资助金额:
-- - 项目类别:
Cherenkov luminescence mediated excitation of discrete lanthanide optical probes
切伦科夫发光介导的离散镧系元素光学探针的激发
- 批准号:
10380890 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Cherenkov luminescence mediated excitation of discrete lanthanide optical probes
切伦科夫发光介导的离散镧系元素光学探针的激发
- 批准号:
10215707 - 财政年份:2021
- 资助金额:
-- - 项目类别:
Synthesis of responsive lanthanide probes for biological imaging
用于生物成像的响应性稀土探针的合成
- 批准号:
2456647 - 财政年份:2020
- 资助金额:
-- - 项目类别:
Studentship
Photon Upconversion Probes with Lanthanide Containing Biomolecules
具有含镧系元素生物分子的光子上转换探针
- 批准号:
2282620 - 财政年份:2019
- 资助金额:
-- - 项目类别:
Studentship
Lanthanide complexes as chiral probes and labels
作为手性探针和标记的镧系元素配合物
- 批准号:
EP/P025013/1 - 财政年份:2017
- 资助金额:
-- - 项目类别:
Research Grant
INSPIRE Track 1: Lanthanide-based probes for visualizing RNAs and proteins in live organisms
INSPIRE Track 1:用于可视化活体生物体中 RNA 和蛋白质的基于镧系元素的探针
- 批准号:
1344038 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Continuing Grant
Lanthanide Metallacrowns as Near-Infrared Fluorescent Probes for Optical Imaging
稀土金属冠作为光学成像的近红外荧光探针
- 批准号:
8709848 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Lanthanide Metallacrowns as Near-Infrared Fluorescent Probes for Optical Imaging
稀土金属冠作为光学成像的近红外荧光探针
- 批准号:
8593456 - 财政年份:2013
- 资助金额:
-- - 项目类别: