Home vs Center-Based Weight Loss & Exercise in Menopause

家庭减肥与中心减肥

• 批准号: 6726067
• 负责人: KAREN E DENNIS
• 金额: $ 43.26万
• 依托单位: UNIVERSITY OF CENTRAL FLORIDA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6726067
• 关键词: Home; vs; Center; Based; Weight

DESCRIPTION (provided by applicant): Multi-faceted obesity treatment demonstrates the best weight loss (WL) outcomes, yet the most effective site and methods for treatment delivery and follow-up remain elusive. Compounding the persistent treatment enigmas, aging in women is associated with an increasingly sedentary lifestyle that reduces total daily energy expenditure, predisposing to obesity. Moreover, candidate genes that contribute to the heritability of body weight and body fat distribution also may influence the response to WL treatment. In a nation with an unrelenting epidemic of obesity, the need for treatment far exceeds the capacity of the health care system to provide care on an individual basis. The purpose of this study is to: 1) assess the effects of a multi-faceted HOME-versus CENTER-based WL program on WL, CVD risk factors, and psychosocial factors; 2) determine whether a multi-faceted HOME- or CENTER-based approach more effectively leads to sustained treatment enrollment; and 3) retrospectively determine whether women with one or more variants in selected obesity-energy expenditure or insulin-sensitivity candidate genes have different outcomes post-treatment and/or at follow-up than women without a genetic predisposition. Overweight or obese (BMI 25-40 kg/m2) women (n=100) at least one year postmenopausal but < 65 years of age will be randomized to receive CENTER- or HOME-based interventions for WL that include low intensity exercise (walking). All women will receive 2 weeks of orientation to CENTER or HOME programs onsite and have baseline data collected before 6-month CENTER or HOME-based programs begin. Evaluation will be in a stable diet and exercise status post intervention, and again after 6 months maintenance at CENTER or HOME. Multivariate analyses will be used to reduce error inflation from multiple comparisons, or Bonferonni corrections will be used when multivariate analyses are not possible. With its health promotion emphasis, nursing is an ideal discipline to conduct and translate research-based, lifestyle-modification WL interventions into practice. WL interventions that postmenopausal women will accept and sustain are essential for promoting health and prevention disease during the period of major vulnerability in their lives.

描述（由申请人提供）：多方面的肥胖治疗证明了最好的减肥（WL）结果，但最有效的治疗部位和方法以及随访仍然难以捉摸。 女性的衰老与越来越多的久坐不动的生活方式有关，这种生活方式减少了每日总能量消耗，易患肥胖症，这加剧了持续的治疗之谜。 此外，影响体重和体脂分布遗传率的候选基因也可能影响WL治疗的反应。 在一个肥胖症持续流行的国家，对治疗的需求远远超过了卫生保健系统提供个人护理的能力。 本研究的目的是：1）评估多方面的家庭与中心为基础的WL计划对WL，CVD危险因素和心理社会因素的影响; 2）确定多方面的家庭或中心为基础的方法是否更有效地导致持续的治疗招募;和3）回顾性地确定在选定的肥胖-能量消耗或胰岛素-敏感性候选基因在治疗后和/或随访时与没有遗传易感性的妇女相比具有不同的结果。 超重或肥胖（BMI 25-40 kg/m2）绝经后至少1年但< 65岁的女性（n=100）将随机接受基于中心或家庭的WL干预，包括低强度运动（步行）。 所有女性将接受为期2周的中心或家庭项目现场指导，并在6个月的中心或家庭项目开始前收集基线数据。 将在干预后的稳定饮食和运动状态下进行评价，并在中心或家庭维持6个月后再次进行评价。 将使用多变量分析来减少多重比较的误差膨胀，或者当不可能进行多变量分析时，将使用Bonferonni校正。 以其健康促进的重点，护理是一个理想的学科进行和翻译为基础的研究，生活方式的修改WL干预措施付诸实践。 绝经后妇女将接受和维持的WL干预措施对于在其生命中的主要脆弱时期促进健康和预防疾病至关重要。