MATERNAL, FETAL & ENVIRONMENTAL CAUSES OF BIRTH DEFECTS
母体、胎儿
基本信息
- 批准号:6786633
- 负责人:
- 金额:$ 45.47万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-09-01 至 2006-05-31
- 项目状态:已结题
- 来源:
- 关键词:clinical researchcongenital oral /facial /cranial defectcraniosynostosisdisease /disorder etiologydisease /disorder proneness /riskembryo /fetus toxicologyenvironmental exposureenvironmental toxicologyfamily geneticsgene environment interactiongene interactiongenetic susceptibilitygenotypehigh throughput technologyhuman subjectmicroarray technologyspina bifida
项目摘要
DESCRIPTION: (Adapted from the Applicant's Description) The current proposal
is based on the premise that a full understanding of the genetic architecture
for many birth defects will only be obtained if "higher-order" effects such as
gene-environment (GxE) interactions, gene-gene (GxG) interactions and maternal
genotypic effects are evaluated in concert with more traditional
epidemiological and genetic risk factors. Moreover, recent advances in
molecular and statistical genetics provide a foundation upon which to build
studies that address the role of higher-order effects, when such effects are
suggested by current understanding of a disease's etiology. The investigators
propose to evaluate the role of GxE interactions, GxG interactions and
maternal effects in the etiology of two groups of birth defects: neural tube
defects and cranial abnormalities including craniosynostosis and nonsynostotic
posterior plagiocephaly (CSINSPP). These conditions were selected from other
potential candidates because current understanding of their etiologies support
multiple hypotheses regarding higher-order effects. Hence, for these
conditions in particular, it is now feasible to begin to construct a multi-
dimensional blueprint of their genetic architecture. They will use state-of-
the-art genotyping methods, including high-throughput array technologies, and
employ state-of-the-art statistical approaches to evaluate the role of higher-
order effects in the etiology of spina bifida and CS/NSPP.
描述:(改编自申请人的描述)当前的提案
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Association between the NAT1 1095C > A polymorphism and homocysteine concentration.
NAT1 1095C > A 多态性与同型半胱氨酸浓度之间的关联。
- DOI:10.1002/ajmg.a.31475
- 发表时间:2006
- 期刊:
- 影响因子:0
- 作者:Stanisławska-Sachadyn,Anna;Jensen,LiselotteE;Kealey,Carmel;Woodside,JayneV;Young,IanS;Scott,JohnM;Murray,Liam;Boreham,ColinA;McNulty,Helene;Strain,JJ;Whitehead,AlexanderS
- 通讯作者:Whitehead,AlexanderS
Spina bifida.
- DOI:10.1038/nrdp.2015.7
- 发表时间:2015-04-30
- 期刊:
- 影响因子:0
- 作者:Copp AJ;Adzick NS;Chitty LS;Fletcher JM;Holmbeck GN;Shaw GM
- 通讯作者:Shaw GM
Exon sequencing of PAX3 and T (brachyury) in cases with spina bifida.
- DOI:10.1002/bdra.23163
- 发表时间:2013-09
- 期刊:
- 影响因子:0
- 作者:Agopian AJ;Bhalla AD;Boerwinkle E;Finnell RH;Grove ML;Hixson JE;Shimmin LC;Sewda A;Stuart C;Zhong Y;Zhu H;Mitchell LE
- 通讯作者:Mitchell LE
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LAURA E. MITCHELL其他文献
LAURA E. MITCHELL的其他文献
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{{ truncateString('LAURA E. MITCHELL', 18)}}的其他基金
Maternal Genes that Control Early Embryonic Development as Risk Factors for Congenital Heart Defects
控制早期胚胎发育的母体基因是先天性心脏病的危险因素
- 批准号:
9982092 - 财政年份:2019
- 资助金额:
$ 45.47万 - 项目类别:
Spina Bifida and Maternal Weight: Moving from Association to Prevention
脊柱裂和母亲体重:从关联转向预防
- 批准号:
9020605 - 财政年份:2015
- 资助金额:
$ 45.47万 - 项目类别:
Seventh, Eighth & Ninth International Neural Tube Defects Conferences
第七、第八
- 批准号:
8204109 - 财政年份:2011
- 资助金额:
$ 45.47万 - 项目类别:
Environmental Determinants of Neural Tube Defects
神经管缺陷的环境决定因素
- 批准号:
6901623 - 财政年份:2005
- 资助金额:
$ 45.47万 - 项目类别:
Dissection of the VCFS phenotype--Palatal anomalies
VCFS表型剖析--腭部异常
- 批准号:
6660516 - 财政年份:2002
- 资助金额:
$ 45.47万 - 项目类别:
Pharmacogenetic Epidemiology of Birth Defects and Cancer
出生缺陷和癌症的药物遗传学流行病学
- 批准号:
6477759 - 财政年份:2002
- 资助金额:
$ 45.47万 - 项目类别:
Dissection of the VCFS phenotype--Palatal anomalies
VCFS表型剖析--腭部异常
- 批准号:
6564045 - 财政年份:2002
- 资助金额:
$ 45.47万 - 项目类别:
Dissection of the VCFS phenotype--Palatal anomalies
VCFS表型剖析--腭部异常
- 批准号:
6414847 - 财政年份:2001
- 资助金额:
$ 45.47万 - 项目类别: