Investigating selection and co-selection for antimicrobial resistance by non-antibiotic drugs and plant protection products

研究非抗生素药物和植物保护产品对抗菌药物耐药性的选择和共同选择

• 批准号: 2288986
• 金额: --
• 依托单位: UNIVERSITY OF EXETER
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2288986
• 关键词: Investigating; selection; co; antimicrobial; resistance

A growing body of research has demonstrated low concentrations of antibiotics can select for antimicrobial resistance. The first paper showing non-antibiotic drugs (NADs) can select for antimicrobial resistance (AMR) in human gut-associated strains has just been published, raising concerns for selection for AMR in vivo. NADs are also present in waste water treatment plants, alongside antibiotics and other antimicrobial compounds where they are present as micropollutants. This cocktail of potentially selective contaminants will be present in sewage sludge, which is applied to agricultural soils as a fertiliser alongside plant protection products (PPP). How these multiple pressures may interact to select for AMR in terrestrial environments and how they impact microbial diversity is a completely novel research area, with the potential to influence policy at an international level, inform sustainable agricultural practices, and improve fundamental understanding of AMR evolution and microbial ecology.

越来越多的研究表明，低浓度的抗生素可以选择抗菌素耐药性。第一篇显示非抗生素药物（NADs）可以选择人类肠道相关菌株中的抗菌素耐药性（AMR）的论文刚刚发表，引起了对体内AMR选择的关注。NAD也存在于废水处理厂中，与抗生素和其他抗菌化合物一起作为微污染物存在。这种潜在的选择性污染物混合物将存在于污水污泥中，作为肥料与植物保护产品（PPP）一起应用于农业土壤。这些多重压力如何相互作用以选择陆地环境中的抗菌素耐药性以及它们如何影响微生物多样性是一个全新的研究领域，有可能影响国际层面的政策，为可持续农业实践提供信息，并提高对抗菌素耐药性进化的基本认识和微生物生态学。