Psychosocial Issues in Umbilical Cord Blood Donation

脐带血捐献中的心理社会问题

• 批准号: 6734199
• 负责人: GALEN E. SWITZER
• 金额: $ 18.58万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6734199
• 关键词: attitude; behavioral /social science research tag; blood banks; blood donor; clinical research; cord blood; decision making; female; health education; hematopoietic tissue transplantation; human population study; human subject; informed consent; psychometrics; questionnaires; satisfaction; social psychology; stem cell transplantation; volunteer; women' s health

As medical advances continue to make the transplantation of stem cells a more successful treatment option for hematologic malignancies, bone marrow failure syndromes, and solid tumor cancers, there will be an increasing need for such cells supplied by unrelated donors. Although these stem cells have traditionally been supplied by living unrelated bone marrow donors who may face significant physical and psychological risks to donate, new procedures of gathering stem cells that may decrease donor risks are currently being explored. One of these procedures involves the collection of umbilical cord blood from mothers who have recently delivered a healthy infant. Although several public cord blood banks have been established in the U.S. to collect and store umbilical cord blood, no studies of donors experiences during and after donation currently exist. Thus, the proposed study is designed to examine the background, psychosocial, and donation-related characteristics of mothers who are approached by representatives of public umbilical cord blood banks and asked to donate their newborn's cord blood for future public use. In addition to description maternal characteristics, we will also investigate the relative influences of these characteristics, and the characteristics and strategies of cord blood banks themselves (e.g., donor selection, education, and consent procedures) on donation-related outcomes (e.g., decision to donate, satisfaction, ambivalence). Cross-sectional questionnaire data will be gathered either 2-3 weeks or 8-9 weeks post delivery from 1,800 mothers who are approached for cold blood donation- and agree or decline to donate by one of three public cord blood banks. In addition, data on cord blood bank characteristics and strategies will be gathered concurrent with maternal data collection. In addition, data on cord blood bank characteristics and strategies will be gathered concurrent with maternal data collection. These data will allow us to (a) describe the characteristics of mothers who agree to (or do not agree to) donate, (b) examine the relationship of maternal background, psychosocial and donation-related outcomes, (c) examine the role of cord blood bank strategies and organization factors in predicting maternal-donation related outcomes, and (d) investigate the synergistic effects of maternal and bank characteristics on donation-related outcomes.

随着医学进步不断使干细胞移植成为血液系统恶性肿瘤、骨髓衰竭综合征和实体瘤癌症更成功的治疗选择，对由无关捐赠者提供的此类细胞的需求将不断增加。尽管这些干细胞传统上是由活体无关的骨髓捐献者提供的，他们可能会面临捐献时重大的身体和心理风险，但目前正在探索可能降低捐献者风险的收集干细胞的新程序。其中一项程序涉及从最近生下健康婴儿的母亲那里收集脐带血。尽管美国已经建立了几个公共脐带血库来收集和储存脐带血，但目前还没有对捐献者在捐献期间和捐献后经历的研究。因此，拟议的研究旨在检查公共脐带血库代表接触并要求捐献新生儿脐带血以供将来公共使用的母亲的背景、心理社会和捐献相关特征。除了描述母亲特征外，我们还将调查这些特征的相对影响，以及脐带血库本身的特征和策略（例如，捐赠者选择、教育和同意程序）对捐赠相关结果（例如，捐赠决定、满意度、矛盾心理）的影响。横断面问卷数据将在产后 2-3 周或 8-9 周从 1,800 名接受冷血捐赠的母亲那里收集，这些母亲同意或拒绝由三个公共脐带血库之一进行捐赠。此外，有关脐带血库特征和策略的数据将与孕产妇数据收集同时收集。此外，有关脐带血库特征和策略的数据将与孕产妇数据收集同时收集。这些数据将使我们能够（a）描述同意（或不同意）捐赠的母亲的特征，（b）检查母亲背景、社会心理和捐赠相关结果的关系，（c）检查脐带血库策略和组织因素在预测母亲捐赠相关结果中的作用，以及（d）调查母亲和银行特征对捐赠相关结果的协同效应。

项目成果

Psychological issues in unrelated living organ transplantation in children.

儿童无关活体器官移植中的心理问题。

• DOI: 10.1111/j.1399-3046.2004.00218.x
• 发表时间: 2004
• 期刊: Pediatric transplantation
• 影响因子: 1.3
• 作者: Dew,MaryAmanda;Switzer,GalenE;DiMartini,AndreaF;Bunzel,Brigitta
• 通讯作者: Bunzel,Brigitta