Promoting "impossible" reactions with force

以武力推动“不可能”的反应

• 批准号: 2291362
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2291362
• 关键词: Promoting; impossible; reactions; force

Mechanical force is a formidable source of energy that, with its ability to distort, bend and stretch chemical bonds, is remarkable in its ability to direct chemical transformations along reaction pathways that are otherwise inaccessible to other methods of activation. The precise control of this force could revolutionise how we build and rearrange molecular structures and change the way we think about chemical transformations. Here we propose to use mechanical force to promote "impossible" reactions by deforming the carbon skeleton of the substrate to facilitate a chemical transformation. Substrates will be embedded in a polymer chain, activated mechanically using high-intensity ultrasound. After its removal from the polymer the substrate will be isolated and characterised to assess the efficiency of the mechanical activation. This project explores some fundamental aspects of the reactivity of molecules under tension and we envision applying this approach to other challenging reactions (such as C-H activation/oxidation), opening new avenues in synthetic organic and material chemistry.

机械力是一种强大的能量来源，它具有扭曲、弯曲和拉伸化学键的能力，能够引导化学转化沿着其他活化方法无法达到的反应途径。对这种力的精确控制可能会彻底改变我们构建和重新排列分子结构的方式，并改变我们对化学转化的看法。在这里，我们建议使用机械力，以促进“不可能”的反应，通过变形的碳骨架的基板，以促进化学转化。基质将嵌入聚合物链中，使用高强度超声波进行机械激活。在从聚合物中除去底物后，将分离并表征底物以评估机械活化的效率。该项目探索了分子在张力下反应性的一些基本方面，我们设想将这种方法应用于其他具有挑战性的反应（如C-H活化/氧化），为合成有机和材料化学开辟新的途径。