Biomedical Alcohol Research Training Program

生物医用酒精研究培训计划

• 批准号: 6748854
• 负责人: GREGORY JOHN BAGBY
• 金额: $ 33.37万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-22 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6748854
• 关键词: Biomedical; Alcohol; Research; Training; Program

DESCRIPTION (provided by applicant): The Biomedical Alcohol Research Training Program will prepare young predoctoral PhD and combined MD/PhD students, and postdoctoral fellows with MD and/or PhD degrees for research careers on the biomedical consequences of alcohol consumption and abuse. Core Faculty will be primarily responsible for mentoring trainees and include 17 scientists from the School of Medicine at LSUHSC (12), School of Public Health & Tropical Medicine at Tulane University (1), Tulane National Primate Research Center (2), Alton Ochsner Medical Foundation (1), and the College of Pharmacy at Xavier University (1), a historically African American university, The Training Program also relies on 17 Support Faculty that are clinicians, veterinarians, and scientists to provide unique resources, specialized training and co-mentoring. Trainees will pursue alcohol research projects under three interrelated themes 1) Alcohol/HIV Disease, 2) Alcohol/Host Defense, 3) Alcohol/Neuroendocrine and Behavior. The Training Program is designed to develop in trainees research and technical skills that will allow them to advance knowledge by conducting hypotheses-driven mechanistic research on the effect of alcohol consumption and abuse on 1) the innate and specific immune system in the context of infection, 2) the transmission, pathogenesis, progression and treatment of simian Immunodeficiency virus disease in non-human primates, 3) HIV protein effects on host defense and heart function, 4) mechanisms of free radical production by liver including the P450 enzyme system and by cells of the host defense system, 5) learning/memory acquisition in the context of SIV disease and neurotransmitter control, 6) trauma induced alterations in neuroendocrine and cardiovascular function and 7) fetal development of brain synaptic connections. Trainee development will be enriched through didactic sessions that are designed to develop their knowledge base in the alcohol research field as well as their written and oral communication skills. By the third year of this funding cycle, 4 predoctoral students (PhD, MD/PhD) and 5 postdoctoral fellows (MD and/or PhD) will be in the Program. For postdoctoral fellows stringent emphasis will be placed on candidates who are committed to a minimum of two full time research training years, with 3 years preferred. Qualified minority and women candidates will be actively recruited, with special emphasis placed on recruitment of predoctoral minority students from Xavier University. The goal of the program is to provide mentorship and focused training so that young MD and PhD scientists can become familiar with the biomedical problems related to alcohol consumption and acquire the tools to do high quality, competitive research.

描述（由申请人提供）：生物医学酒精研究培训计划将为年轻的博士前博士生和医学博士/博士生以及具有医学博士和/或博士学位的博士后研究员做好准备，从事有关酒精消费和滥用的生物医学后果的研究职业。核心教师将主要负责指导学员，包括来自LSUHSC医学院（12），杜兰大学公共卫生与热带医学学院（1），杜兰国家灵长类动物研究中心（2），Alton Ochsner医学基金会（1）和泽维尔大学药学院（1）的17名科学家，这是一所历史上的非洲裔美国大学，培训计划还依赖于17个支持教师，他们是临床医生，兽医和科学家，提供独特的资源，专业培训和共同指导。学员将在三个相互关联的主题下进行酒精研究项目：1）酒精/艾滋病，2）酒精/宿主防御，3）酒精/神经内分泌和行为。培训计划旨在培养学员的研究和技术技能，使他们能够通过进行假设驱动的机制研究来提高知识，研究酒精消费和滥用对1）感染背景下的先天和特异性免疫系统的影响，2）非人灵长类动物中猿猴免疫缺陷病毒病的传播，发病机制，进展和治疗，3）HIV蛋白对宿主防御和心脏功能的影响，4）肝脏（包括P450酶系统）和宿主防御系统细胞产生自由基的机制，5）SIV疾病和神经递质控制背景下的学习/记忆获得，6）创伤引起神经内分泌和心血管功能的改变; 7）胎儿脑突触连接的发育。 培训生的发展将通过旨在发展他们在酒精研究领域的知识基础以及他们的书面和口头沟通技能的教学会议来丰富。到本资助周期的第三年，4名博士前学生（博士，医学博士/博士）和5名博士后研究员（医学博士和/或博士）将参加该计划。对于博士后研究员，将严格强调那些致力于至少两个全职研究培训年的候选人，最好是3年。将积极招聘合格的少数民族和妇女候选人，特别重视招聘泽维尔大学的博士前少数民族学生。该计划的目标是提供指导和重点培训，使年轻的医学博士和博士科学家能够熟悉与酒精消费相关的生物医学问题，并获得进行高质量，有竞争力的研究的工具。