NFKB ACTIVATION IN PNEUMOCOCCUS AND SIV-COINFECTED LUNGS

肺炎球菌和 SIV 合并感染的肺部中 NFKB 激活

• 批准号: 7165057
• 负责人: GREGORY JOHN BAGBY
• 金额: $ 5.45万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7165057
• 关键词: Primates; animal colony

DESCRIPTION (provided by applicant): This application requests funding for the TNPRC for the five-year period beginning May 1, 2003 through April 30, 2008. Funds will be used to support the administration, operations, veterinary resources, and scientific research resources of the Center. Additional funds to support pilot research projects and colony-health-related research resource projects are also requested. The research program at the TNPRC has been focused on infectious disease research for close to three decades. Although the majority of the Center's research efforts are devoted to infectious disease, there are also rapidly expanding programs in gene therapy and assisted reproductive technologies (ART). The infectious disease program currently focuses on AIDS, Malaria Microsporidial diseases, and Lyme disease. These are multidisciplinary studies involving investigators in numerous Divisions at the TNPRC as well as collaborators outside the Center. The studies cover the spectrum from transmission, diagnosis and pathogenesis, development of vaccine strategies and chemotherapeutic treatments, and pathologic lesions to gene sequences. In addition, the development of the gene therapy program allows for novel approaches to the treatment of many types of disease and preclinical modeling of a variety of gene therapy modalities. The last five years, and particularly the last year, have seen significant changes at the Center, following the retirement of Dr. Peter Gerone and the naming of Dr. Andrew Lackner as the new Director. Since October 1, 2001 when Dr. Lackner became Director, leadership in several of the Divisions has changed, new Divisions have been formed, and the business office (now Administrative Services) has begun reorganization. The result is a Center that now places more emphasis on research programs and which has experienced a 50% growth in its grant portfolio. These changes have been facilitated by a very helpful and collegial host institution. The new organizational structure and leadership team at the TNPRC and recent successes in obtaining grant funding and attracting outside collaboration suggest that the Center is poised for a period of significant growth and improvement.

描述(由申请人提供)： 本申请申请从2003年5月1日起至2008年4月30日止的五年期间向国家技术合作研究中心申请资金。资金将用于支持该中心的管理、运营、兽医资源和科研资源。还要求提供额外资金，以支持试点研究项目和与群体健康有关的研究资源项目。近30年来，TNPRC的研究计划一直专注于传染病研究。尽管该中心的大部分研究工作都致力于传染病，但在基因治疗和辅助生殖技术(ART)方面也有迅速扩大的项目。传染病方案目前的重点是艾滋病、疟疾、微孢子虫病和莱姆病。这些研究是多学科研究，涉及TNPRC许多部门的调查人员以及中心外的合作者。这些研究涵盖了从传播、诊断和发病机制、疫苗策略和化疗治疗的发展，以及从病理损伤到基因序列的范围。此外，基因治疗计划的开发还允许采用新的方法来治疗多种疾病，并对各种基因治疗模式进行临床前建模。过去五年，特别是去年，在彼得·杰隆博士退休并任命安德鲁·拉克纳博士为新主任之后，中心发生了重大变化。自2001年10月1日拉克纳博士担任主任以来，几个部门的领导层发生了变化，成立了新的部门，业务办公室(现在的行政部门)已经开始重组。其结果是，该中心现在更加重视研究计划，其赠款组合经历了50%的增长。这些变化得到了一个非常有帮助和合作的主办机构的推动。TNPRC的新组织结构和领导团队以及最近在获得赠款资金和吸引外部合作方面取得的成功表明，该中心即将迎来一个显著的增长和改善时期。