ER stress-Unfolded Protein Response a critical metabolic pathway for airway remodelling in asthma

内质网应激-未折叠蛋白反应是哮喘气道重塑的关键代谢途径

• 批准号: nhmrc : 2002953
• 金额: $ 78.95万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/er-stress-unfolded-remodelling-asthma/1780044
• 关键词: ER; stress; Unfolded; Protein; Response

Airway remodelling in asthma is associated with poor clinical outcomes and is not prevented by current treatments. We have found endoplasmic reticulum stress (ERS) and associated unfolded protein response (UPR), a crucial process involve in cellular protein folding, play a key role in airway remodelling in asthma. This study will investigate whether inhibition of ERS prevents goblet cell metaplasia, mucus hypersecretion and fibrosis and can be used as a therapeutic strategy for severe asthma.

哮喘的气道重塑与不良的临床结局相关，目前的治疗方法无法预防。内质网应激（endoplasmic reticulum stress，ERS）及其相关的未折叠蛋白反应（unfolded protein response，UPR）是细胞蛋白质折叠的关键过程，在哮喘气道重塑中起重要作用。本研究将探讨抑制ERS是否可预防杯状细胞化生、粘液分泌过多和纤维化，并可用作重度哮喘的治疗策略。