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Apoptotic Cell Removal in Idiopathic Pulmonary Fibrosis

Apoptotic Cell Removal in Idiopathic Pulmonary Fibrosis
特发性肺纤维化中的凋亡细胞去除
批准号：
6831107
负责人：
Harold R Collard
金额：
$5.03万
依托单位：
NATIONAL JEWISH HEALTH
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
项目状态：
已结题
起止时间：
2004-07-16 至 2005-05-31
来源：
https://reporter.nih.gov/project-details/6831107
关键词：
agingalveolar macrophagesapoptosisclinical researchfibroblastshuman old age (65+)human subjectidiopathic pulmonary fibrosismacrophagepathologic processpatient oriented researchphagocytosispostdoctoral investigatortransforming growth factors

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英文摘要
DESCRIPTION (provided by applicant): This research proposal aims to investigate and define abnormalities in apoptosis and the removal of apoptotic cells in patients with Idiopathic Pulmonary Fibrosis (IPF). We hypothesize that abnormalities in apoptosis and apoptotic cell removal lead to increased TGF-beta 1 activity and contribute to the development of pulmonary fibrosis in this disease. There are two specific aims to this proposal: Specific Aim 1: To define abnormalities in apoptosis and apoptotic cell removal in IPF. Specific Aim 2: To determine the relationship between apoptosis, apoptotic cell removal and TGF-beta 1 production in IPF. Human monocyte derived macrophages, alveolar macrophages and lung fibroblasts will be obtained from subjects with IPF and normal age-matched controls. Apoptosis of these cells, and the ability of these cells to remove apoptotic cells will be determined. Apoptosis and apoptotic cell removal in IPF will be correlated with the degree of TGF-beta 1 production.
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会议论文
Natural History of Viral Induced Airway Dysfunction and Asthma in Minority Children
Clinical and Translational Science Institute
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Patient Oriented Research and Mentoring in Interstitial Lung Disease
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