Understanding Skin Permeation of Agrochemicals using Mass Spectrometry Imaging

已建立的评估皮肤渗透性的方法仅提供了对通过皮肤的整体释放的洞察，诺丁汉大学最近进行的工作表明，成像质谱学技术可以详细说明这一点，以更好地了解活性物质在皮肤组织中的释放并显示其定位。该项目旨在利用这些技术，通过突出皮肤、渗透途径和给药机制，进一步了解农用化学成分的吸收情况。该项目的发现将使先正达的产品开发成为可能，并最终降低接触农用化学品用户的风险。申请者将在诺丁汉大学一个成熟的皮肤渗透小组工作，利用3DOrbiSIMS(https://www.nottingham.ac.uk/nmrc/facilities/orbisims/orbitrap-sims.aspx)等独特的最先进设施，提供以前无法获得的关于农用化学品渗透到皮肤以及它们对彼此渗透特性渗透性的影响的见解。

Established methodologies of assessing skin permeation only provide an insight into overall delivery through skin, more recent work undertaken at The University of Nottingham has demonstrated that imaging mass spectrometry techniques can elaborate on this to better understand the delivery of active agents within skin tissue and demonstrate their localisation. This project aims to utilise these techniques to further the understanding of the uptake of agrochemical components through skin highlighting routes of permeation and mechanisms of delivery. The findings from this project will enable product development at Syngenta and ultimately reduce the risks of exposure to agrochemical users.The applicant will work within an established skin permeation group at the University of Nottingham utilising unique state of the art facilities such as the 3D OrbiSIMS (https://www.nottingham.ac.uk/nmrc/facilities/orbisims/orbitrap-sims.aspx) to provide previously unavailable insight into the permeation of agrochemicals into skin as well as their impact upon the permeability of each other's permeation characteristics.