Transportable Chlorine Dioxide Sterilization System

便携式二氧化氯灭菌系统

• 批准号: 6736623
• 负责人: Stuart K Williams
• 金额: $ 10万
• 依托单位: PARE TECHNOLOGIES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736623
• 关键词: Bacillus subtilis; antiinfective agents; bioengineering /biomedical engineering; biomaterial compatibility; biomedical equipment development; chlorine; cytotoxicity; disinfectants; iatrogenic disease; nosocomial infections; portable biomedical equipment; spores

DESCRIPTION (provided by applicant): Medical infections remain a major cause of morbidity and mortality in the United States. The proposed studies have a primary goal to develop a transportable sterilization cabinet for use in patient care facilities including hospital, clinics, physician offices and assisted living environments. Chlorine dioxide gas will be used as the sterilizing agent. A major methodological goal of this program is the development of a disposable chlorine dioxide generating system to be used with the transportable cabinet. A major advantage of the proposed system is the use of chlorine dioxide gas with its established ability to kill a wide range of microbes including bacteria, viruses, mold and fungi. Three specific aims have been developed to evaluate the feasibility of this sterilization unit. Specific Aim 1. will evaluate optimal concentrations of chlorine dioxide and treatment times necessary to provide sporicidal activity. Specific Aim 2. will evaluate the effect of CIO2 sterilization on medical instrument material characteristics. Specific Aim 3. will evaluate the efficacy of a prototype commercial sterilization unit and disposable gas generation system using reusable medical instruments as a test system. Following completion of these studies Phase II funding will be sought to optimize and commercialize a transportable sterilization unit.

描述（由申请人提供）： 在美国，医疗感染仍然是发病率和死亡率的主要原因。拟议的研究的主要目标是开发可运输的灭菌柜，用于用于患者护理设施，包括医院，诊所，医师办公室和辅助生活环境。二氧化氯气将用作灭菌剂。该计划的主要方法论目标是开发可与可运输机柜一起使用的一次性二氧化氯生成系统。该系统的一个主要优点是使用二氧化氯气，其既有杀死包括细菌，病毒，霉菌和真菌在内的广泛微生物的能力。已经开发了三个特定的目标来评估该灭菌单元的可行性。 具体目标1。将评估提供孢子活性所需的最佳二氧化氯和治疗时间。 具体目标2。将评估CIO2灭菌对医疗仪器材料特征的影响。 具体目标3。将评估使用可重复使用的医疗仪器作为测试系统的原型商业灭菌单元和一次性气体产生系统的功效。完成这些研究后，将寻求II阶段资金来优化和商业化可运输的灭菌单元。