Polarized Xenon Production: Compact Magnetic Field

偏振氙气生产：紧凑磁场

• 批准号: 6833211
• 负责人: F. WILLIAM HERSMAN
• 金额: $ 10.15万
• 依托单位: XEMED, LLC
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-21 至 2005-07-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833211
• 关键词: bioimaging /biomedical imaging; computer program /software; contrast media; lung imaging /visualization /scanning; magnetic field; magnetic resonance imaging; mathematical model; reagent /indicator; respiratory disorder diagnosis; technology /technique development; xenon

DESCRIPTION (provided by applicant): Since its first demonstration as an imaging agent in MRI nearly a decade ago, the promise of hyperpolarized xenon has captured the attention of the research community. It can be introduced into a subject non-invasively by breathing, and has a well-understood short-term biological effect. Relative to hyperpolarized helium, its advantages include its natural abundance and low cost. Both hyperpolarized xenon and helium have demonstrated utility in lung imaging, and quantifying lung disease. In contrast to helium, however, hyperpolarized xenon has a high solubility in fluids and tissues and a characteristic chemical shift, revealing its microscopic environment in dissolved-phase imaging. Consequently, the time dependence of its transport and absorption offer prospects for functional imaging of perfusion. Using NIH R21 and R15 funds, the UNH group demonstrated a new type of xenon polarizer that flows the gas mixture at relatively high velocity and low pressure along a direction opposite to the laser beam. This polarizer demonstrated polarization of almost 50% for a production rate of one liter per hour. The figure-of-merit (polarization times production rate) of this polarizer presently exceeds all other polarizer technologies by an order of magnitude. We request STTR funding to develop a novel magnetic subsystem incorporating coil windings, permanent magnets, and shielding iron to reduce the size (footprint) of this polarizer by a factor of three, and substantially reduce its sitting requirements. This development helps to convert this laboratory installation to a practical hospital-based device. Hyperpolarized gas has already demonstrated utility in diagnosing and quantifying lung disease. We present technological, physiological, and economic arguments that hyperpolarized xenon can and perhaps will surpass gadolinium as the contrast agent of choice in a broad spectrum of diagnostic imaging protocols.

描述（由申请人提供）： 自从近十年前在MRI中首次展示作为成像剂以来，超极化氙的前景引起了研究界的关注。它可以通过呼吸非侵入性地引入受试者体内，并具有众所周知的短期生物效应。相对于超极化氦，其优势包括其天然丰度和低成本。超极化氙和氦都已被证明可用于肺部成像和肺部疾病的定量。然而，与氦相反，超极化氙在液体和组织中具有高溶解度和特征化学位移，在溶解相成像中揭示了其微观环境。因此，其运输和吸收的时间依赖性为灌注功能成像提供了前景。利用NIH R21和R15基金，UNH小组展示了一种新型的氙偏振器，该偏振器使气体混合物以相对较高的速度和沿着与激光束相反的方向流动。该偏振器在每小时1升的生产速率下显示出几乎50%的偏振。该偏振器的品质因数（偏振乘以生产率）目前超过所有其他偏振器技术一个数量级。 我们要求STTR资助开发一种新型的磁性子系统，包括线圈绕组，永磁体和屏蔽铁，以将该偏振器的尺寸（占地面积）减少三分之一，并大大降低其坐要求。这一发展有助于将该实验室装置转换为实际的医院设备。 超极化气体已经证明在诊断和量化肺部疾病中的实用性。我们提出的技术，生理和经济的论点，超极化氙可以，也许会超过钆作为造影剂的选择，在广泛的诊断成像协议。