NOVEL GAS POLARIZATION METHOD FOR HYPERPOLARIZED XE MRI

用于超偏振 XE MRI 的新型气体偏振方法

• 批准号: 6056612
• 负责人: F. WILLIAM HERSMAN
• 金额: $ 10.25万
• 依托单位: UNIVERSITY OF NEW HAMPSHIRE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-30 至 2001-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6056612
• 关键词: bioimaging /biomedical imaging; magnetic resonance imaging; method development; xenon

Hyperpolarized xenon magnetic resonance imaging (MRI) offers potential as a new diagnostic research and clinical tool for animals and humans. Inhaled and in the gas phase, it can provide structural information about lungs. Due to its high solubility in blood and tissues, it can also provide functional images of lungs. As it is absorbed into the system, it can provide images of the cardiovascular system and highly perfused organs. Since xenon is lipophilic it offers particular promise as a contrast agent for the white matter of the brain, not distinguishable with present MRI techniques. The principal obstacle to exploiting this modality is low availability and quality of hyperpolarized gas. Researchers at the University of New Hampshire have extensive experience in hyperpolarization of noble gases. We have been polarizing 3He for nuclear physics experiments for over six years. One year ago, the UNH group joined a multi-disciplinary collaboration to apply their expertise to MRI studies. In this proposal, we describe a new approach to achieving a high degree of xenon hyperpolarization with a excellent gas polarization rate. We intend to implement a newly conceived component in the gas polarization process, as well as rigorously apply procedures of optimization. We propose to assemble, test, modify and improve a high capacity xenon polarizer to explore the range of variables in the polarization process, to test the hypothesis that our new design will yield large quantities of highly polarized xenon for MRI studies. Researchers at the Brigham and Women's Hospital have extensive experience in MRI, including hyperpolarized xenon MRI. We will perform initial MRI scans of phantoms and model tissues under this grant. We will also use the hyperpolarized xenon gas to perform more exhaustive studies of biological systems in the context of other grants under the full collaboration. Only with an abundant supply of hyperpolarized xenon will we be able to test the hypothesis that the routine availability of large quantities of xenon, hyperpolarized to a high degree, will lead to new advances in imaging.

超极化氙磁共振成像（MRI）提供了潜在的 作为动物和人类的新诊断研究和临床工具。 在吸入和气相中，它可以提供结构信息 关于肺 由于其在血液和组织中的高溶解度，它可以 还提供肺部的功能图像。 当它被吸收到 系统，它可以提供心血管系统的图像， 灌注的器官 由于氙是亲脂性的， 作为大脑白色物质的造影剂， 与目前的MRI技术相区别。 的主要障碍 利用这种方式是低可用性和质量的 超极化气体 新罕布什尔州大学的研究人员有着丰富的经验 惰性气体的超极化。 我们一直在极化3He 从事核物理实验六年多。 一年前，UNH 小组加入了一个多学科的合作，以应用他们的专业知识 MRI研究。 在本提案中，我们描述了一种新的方法， 用优良的气体实现高度的氙超极化 极化率 我们打算实施一个新构想的组成部分， 在气体极化过程中，以及严格应用程序 的优化。 我们建议组装、测试、修改和改进一个 高容量氙偏振器，以探索变量的范围内， 极化过程，以测试我们的新设计将 产生大量的高极化氙用于MRI研究。 布里格姆妇女医院的研究人员进行了广泛的 MRI经验，包括超极化氙MRI。 我们将执行 在此资助下，对模型和模型组织进行初步MRI扫描。 我们 还将使用超极化氙气， 生物系统研究的其他赠款金 全面合作。 只有有充足的超极化 我们就能验证这个假设 大量氙的可用性，超极化到高 度，将导致成像的新进展。