Novel Skin Barrier to Prevent and Treat Poison Ivy

预防和治疗毒藤的新型皮肤屏障

• 批准号: 6833377
• 负责人: Charles J Gauntt
• 金额: $ 13.37万
• 依托单位: BIOMEDICAL DEVELOPMENT CORPORATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-10 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6833377
• 关键词: biomaterial evaluation; biomaterial interface interaction; clinical research; clinical trials; contact dermatitis; disease /disorder prevention /control; human subject; human therapy evaluation; plant poisons; polyacrylamide; polymers; polyvinyls; skin absorption; surface coating; topical drug application

DESCRIPTION (provided by applicant): Poison ivy/oak dermatitis (also known as Toxicodendron dermatitis) is the most common allergic contact dermatitis in the United States, affecting millions of Americans every year. The prevalence of poison ivy and oak sensitivity in the general adult population ranges from 50 to 70%, and the sensitivity and severity of skin inflammation can range from minor irritation to that which requires medical attention. Topical corticosteroids are the main form of treatment for poison ivy/oak irritations, however the tendency to develop secondary infection can be enhanced by the use of topical or systemic corticosteroids. The goal of this project is to evaluate a patented polymer-based coating technology as both a skin barrier to and treatment for poison ivy and poison oak dermatitis. The innovative coating is expected to provide a safe, antimicrobial, anti-inflammatory skin barrier product that may prevent and treat poison ivy/oak dermatitis. In order to demonstrate feasibility and effectiveness of using the coatings as a barrier and treatment, the following Specific Aims will be pursued: 1. Optimize Coating Formulations and Compound Formulations for Clinical Testing 2. Evaluate Coatings as a Skin Barrier and Treatment for Toxicodendron Dermatitis in Humans

描述（由申请人提供）：