Novel Skin Barrier to Prevent and Treat Poison Ivy

描述(由申请人提供)： 毒藤/橡树皮炎(又称毒葛皮炎)是美国最常见的过敏性接触性皮炎，每年影响数百万美国人。毒藤和橡树过敏在普通成年人中的流行率从50%到70%不等，皮肤炎症的敏感性和严重程度从轻微的刺激到需要医疗护理的程度不等。局部皮质类固醇是毒藤/橡树刺激的主要治疗形式，但局部或全身使用皮质类固醇可增加继发感染的倾向。 该项目的目标是评估一种获得专利的聚合物涂层技术作为毒藤和毒橡树皮炎的皮肤屏障和治疗方法。这种创新的涂层有望提供一种安全、抗菌、消炎的皮肤屏障产品，可以预防和治疗毒藤/橡树皮炎。 为了证明使用涂层作为屏障和处理的可行性和有效性，将追求以下具体目标： 1.优化包衣配方和化合物配方，用于临床试验 2.评价涂层作为人体皮肤屏障和治疗弓形虫皮炎的作用

DESCRIPTION (provided by applicant): Poison ivy/oak dermatitis (also known as Toxicodendron dermatitis) is the most common allergic contact dermatitis in the United States, affecting millions of Americans every year. The prevalence of poison ivy and oak sensitivity in the general adult population ranges from 50 to 70%, and the sensitivity and severity of skin inflammation can range from minor irritation to that which requires medical attention. Topical corticosteroids are the main form of treatment for poison ivy/oak irritations, however the tendency to develop secondary infection can be enhanced by the use of topical or systemic corticosteroids. The goal of this project is to evaluate a patented polymer-based coating technology as both a skin barrier to and treatment for poison ivy and poison oak dermatitis. The innovative coating is expected to provide a safe, antimicrobial, anti-inflammatory skin barrier product that may prevent and treat poison ivy/oak dermatitis. In order to demonstrate feasibility and effectiveness of using the coatings as a barrier and treatment, the following Specific Aims will be pursued: 1. Optimize Coating Formulations and Compound Formulations for Clinical Testing 2. Evaluate Coatings as a Skin Barrier and Treatment for Toxicodendron Dermatitis in Humans