Novel Rinse to Treat Oral Candidiasis in Cancer Patients

描述(由申请人提供)： 该项目的目标是开发一种独特、安全和有效的含漱液来治疗癌症患者的口腔念珠菌病。口腔念珠菌病或口腔鹅口疮是一种由所有种类的念珠菌引起的疾病，是免疫抑制人群的常见感染，特别是癌症患者。如果不钝化，口腔念珠菌病可能会转变为食道念珠菌病或危及生命的念珠菌病。大多数假丝酵母菌的大多数细胞。存在于口腔中的一种独特的生态群落中，称为生物膜。包裹在生物膜环境中的细胞比自由生活的独立念珠菌对抗真菌漱口水和药物的抵抗力要强得多，因此影响了治疗的有效性。此外，最有效的漱口水也有几种风险和副作用，包括引起潜在过敏、牙周炎加重、牙齿上的牙垢增加、牙釉质侵蚀和改变对食物的鉴赏力。 在之前的工作中，Biomedical Development Corporation已经开发出一种安全有效的广谱抗菌剂LODILD(R)，已被证明在生物膜存在的情况下有效。这一第一阶段项目的目的是证明使用杀菌剂作为口腔含漱剂治疗癌症患者口腔念珠菌病的可行性。为实现这一目标，将落实以下具体目标： 具体目标1.优化杀菌剂配方，用于治疗口腔念珠菌病 具体目的2.论证杀菌剂对白色念珠菌和混合念珠菌的杀灭效果。生物膜中的细胞 具体目标3.证明杀虫剂配方的安全性

DESCRIPTION (provided by applicant): The goal of this project is to develop a unique, safe and efficacious mouth rinse to treat oral candidiasis in patients with cancer. Oral candidiasis or oral thrush is a disease caused by all species of the fungus Candida and is a common infection for immunosuppressed individuals, particularly cancer patients. If not blunted, oral candidiasis can transit to esophageal candidiasis or life-threatening candidemia. The majority of cells of most Candida sp. exist in the oral cavity in a unique ecologic community known as a biofilm. Cells in the encased setting of biofilms are far more resistant to antifungal mouth rinses and drugs than free-living unattached Candida, thus compromising the effectiveness of treatment. In addition, the most effective mouth rinses have several risks and adverse side effects, including induction of potential allergies, exacerbation of periodontitis, increasing tartar on teeth, erosion of enamel and altering of the appreciation for foods. In previous work, Biomedical Development Corporation has developed locide(r), a safe and efficacious broad-spectrum antimicrobial that has been demonstrated to be effective in the presence of biofilm. The objective of this Phase I project is to demonstrate the feasibility of using locide as a mouth rinse for the treatment of oral candidiasis in cancer patients. To achieve this goal, the following Specific Aims will be executed: Specific Aim 1. Optimize locide Formulation for Use in Treating Oral Candidiasis Specific Aim 2. Demonstrate the Effectiveness of locide in Killing Candida albicans and Mixed Candida sp. Cells in Biofilms Specific Aim 3. Demonstrate Safety of locide Formulations