Establishing the clinical spectrum and pathogenicity of antibodies against dopamine receptors in autoimmune movement and psychiatric disorders

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Dopamine plays a pivotal role in neurotransmission and the control of movement and behaviour. This project aims to define the clinical spectrum and pathogenicity of anti-dopamine receptor antibody mediated diseases. The identification of these antibodies in atypical presentations of common movement disorders would have widespread diagnostic and therapeutic implications, and suggests that selected patients might be amenable to targeted immunomodulatory therapy, thus improving their outcome.