BIOACTIVE-ABSORBABLE COIL FOR BRAIN ANEURYSM THERAPY

用于脑动脉瘤治疗的生物活性可吸收弹簧圈

• 批准号: 6656321
• 负责人: FERNANDO VINUELA
• 金额: $ 51.44万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-10 至 2005-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6656321
• 关键词: biodegradable product; bioimaging /biomedical imaging; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; blood coagulation; blood vessel prosthesis; cerebral aneurysm; disease /disorder model; histology; medical implant science; nonhuman therapy evaluation; polymers; swine; therapeutic blood vessel occlusion; thromboembolism

DESCRIPTION (provided by applicant): Guglielmi detachable coils (GDCs) are the gold standard for endovascular treatment of brain aneurysms. However, GDCs appear to be less effective in wide-necked aneurysms (> 4mm). We propose to develop a new, bio-active, bio-absorbable polymeric material (BPM) coil that improves aneurysm healing by accelerating clot maturation and organization within the aneurysm. We hypothesize that aneurysm healing can be controlled by using BPMs. LONG-TERM OBJECTIVE: To improve clinical management of brain aneurysms by overcoming the present limitations of GDC system. The knowledge of the bio-molecular cascade eliciting aneurysm healing will allow its manipulation and development of better embolic agents. IMMEDIATE OBJECTIVE: 1) Bio-molecular and histological evaluations of natural thrombus formation in surgically created aneurysm. Special attention will be paid on cytokine expression related to clot maturation. 2) In-vitro evaluation of physical, chemical and degradation properties of commercially available Polymers for potential application in brain aneurysm therapy. 3) Utilization of a lateral aneurysm model in swine to evaluate anatomical and histological effects of different bioabsorption properties of commercially available Polymers and their impact in aneurysm healing. 4) Transform current GDC technology to bioactive surface GDC (Hybrid BPM/GDC) and evaluation of angiographic and histological effectiveness of a Hybrid BPWGDC coil. 5) Development of a 100 percent bio-absorbablehio-active intravascular coil for endovascular embolization of intracranial aneurysms

描述（由申请人提供）：Guglielmi 可拆卸弹簧圈 (GDC) 是脑动脉瘤血管内治疗的黄金标准。然而，GDC 对于宽颈动脉瘤（> 4mm）似乎效果较差。我们建议开发一种新型生物活性、生物可吸收聚合材料（BPM）弹簧圈，通过加速动脉瘤内的凝块成熟和组织来改善动脉瘤愈合。我们假设可以通过使用 BPM 来控制动脉瘤愈合。 长期目标：通过克服 GDC 系统目前的局限性来改善脑动脉瘤的临床治疗。对引起动脉瘤愈合的生物分子级联的了解将使其能够操纵和开发更好的栓塞剂。 近期目标：1) 对手术产生的动脉瘤中自然血栓形成进行生物分子和组织学评估。将特别关注与凝块成熟相关的细胞因子表达。 2) 对市售聚合物的物理、化学和降解特性进行体外评估，以用于脑动脉瘤治疗的潜在应用。 3) 利用猪的侧动脉瘤模型来评估市售聚合物的不同生物吸收特性的解剖学和组织学效应及其对动脉瘤愈合的影响。 4) 将当前的 GDC 技术转变为生物活性表面 GDC（混合 BPM/GDC），并评估混合 BPWGDC 线圈的血管造影和组织学有效性。 5) 开发100%生物可吸收的生物活性血管内弹簧圈，用于颅内动脉瘤的血管内栓塞