BIOACTIVE-ABSORBABLE COIL FOR BRAIN ANEURYSM THERAPY

描述(申请人提供)：电解可脱性弹簧圈(GDC)是血管内治疗脑动脉瘤的黄金标准。然而，GDC在宽颈动脉瘤(&gt；4 mm)中似乎效果较差。我们建议开发一种新的、生物活性的、生物可吸收的聚合物材料(BPM)弹簧圈，通过加速动脉瘤内血栓的成熟和组织来改善动脉瘤的愈合。我们假设使用BPM可以控制动脉瘤的愈合。 长期目标：克服目前GDC系统的局限性，提高脑动脉瘤的临床治疗水平。对诱导动脉瘤愈合的生物分子级联反应的了解将使其操作和开发更好的栓塞剂。 近期目标：1)外科手术形成的动脉瘤中自然血栓形成的生物分子和组织学评价。将特别关注与血栓成熟相关的细胞因子的表达。2)体外评价商用聚合物的物理、化学和降解性能，为其在脑动脉瘤治疗中的潜在应用。3)利用猪的侧方动脉瘤模型，评价不同生物吸收特性的商品聚合物的解剖和组织学效应及其对动脉瘤愈合的影响。4)将现有的GDC技术转化为生物活性表面GDC(杂交BPM/GDC)，并对其血管造影和组织学效果进行评价。5)研制一种100%生物可吸收的高活性血管内弹簧圈，用于颅内动脉瘤的血管内栓塞

DESCRIPTION (provided by applicant): Guglielmi detachable coils (GDCs) are the gold standard for endovascular treatment of brain aneurysms. However, GDCs appear to be less effective in wide-necked aneurysms (> 4mm). We propose to develop a new, bio-active, bio-absorbable polymeric material (BPM) coil that improves aneurysm healing by accelerating clot maturation and organization within the aneurysm. We hypothesize that aneurysm healing can be controlled by using BPMs. LONG-TERM OBJECTIVE: To improve clinical management of brain aneurysms by overcoming the present limitations of GDC system. The knowledge of the bio-molecular cascade eliciting aneurysm healing will allow its manipulation and development of better embolic agents. IMMEDIATE OBJECTIVE: 1) Bio-molecular and histological evaluations of natural thrombus formation in surgically created aneurysm. Special attention will be paid on cytokine expression related to clot maturation. 2) In-vitro evaluation of physical, chemical and degradation properties of commercially available Polymers for potential application in brain aneurysm therapy. 3) Utilization of a lateral aneurysm model in swine to evaluate anatomical and histological effects of different bioabsorption properties of commercially available Polymers and their impact in aneurysm healing. 4) Transform current GDC technology to bioactive surface GDC (Hybrid BPM/GDC) and evaluation of angiographic and histological effectiveness of a Hybrid BPWGDC coil. 5) Development of a 100 percent bio-absorbablehio-active intravascular coil for endovascular embolization of intracranial aneurysms