Learning Within the Spinal Cord: Clinical Implications

脊髓内的学习：临床意义

• 批准号: 6621602
• 负责人: James William Grau
• 金额: $ 38.19万
• 依托单位: TEXAS A&M UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6621602
• 关键词: behavior test; behavioral /social science research tag; conditioning; fos protein; functional ability; immunocytochemistry; laboratory rat; learning; neural plasticity; neurochemistry; spinal cord; spinal cord injury

DESCRIPTION (provided by applicant): Traditionally, the spinal cord has been viewed as a conduit between the brain and the periphery, organizing some simple reflexes but otherwise contributing little to learning and behavior. However, recent studies suggest that a great deal of information processing occurs within the spinal cord, and that this system not only tunes the afferent and efferent input/output at the brain's bidding but also adapts on its own to new environmental relations. Learning within the spinai cord can be studied using rats that have had the spinal cord cut at the second thoracic vertebra. A response-outcome contingency is established by applying shock to one hindleg whenever the leg falls below a preset criterion. Spinal neurons appear sensitive to this instrumental contingency, for subjects quickly learn to maintain their leg in a flexed position, effectively minimizing exposure to shock. This instrumental learning is facilitated by prior exposure to contingent shock and disrupted by noncontingent shock. It appears contingent training enables behavioral potential while noxious noncontingent stimuli undermine behavioral potential. The proposed experiments focus on the mechanisms that foster and preserve behavioral plasticity within the spinal cord and the implications of this work for the recovery of function after spinal cord injury. Studies proposed will examine the retention of the facilitory effect, the impact of Pavlovian contingencies, and whether clinically relevant stimuli (nerve injury, inflammation) affect behavioral potential. It is suggested that some neurochemical systems (noradrenergic, and/or serotonergic) may help preserve behavioral potential. Experiments will examine whether engaging these systems protects the spinal cord from the deleterious effects of noncontingent noxious stimuli. Finally, studies will explore the underlying mechanisms using immunocytochemical techniques (c-fos) and whether the experimental manipulations affect the recovery of locomotor behavior after a contusion injury. It is hoped that discovering the mechanisms that promote and protect behavioral plasticity within the spinal cord will lead to new behavioral and pharmacological treatments that foster recovery of function after spinal cord injury.

描述（由申请人提供）：传统上，脊髓一直是