CORE--BIOPHYSICS AND ELECTROPHYSIOLOGY

这个核心不是基于现有的核心，而是代表了一个新的概念，可能会增加大量神经科学研究者的研究能力，并促进合作。本核心的目标是为电生理实验提供设备以及进行实验的技术能力。这将允许神经科学研究人员进行初步实验，以测试将电生理学方法应用于正在进行的项目的可行性。此外，核心将为神经科学研究者提供一个明确的场所，以获得有关在自己的实验室建立电生理方法的专家建议。这个核心将位于附近

This Core is not based on an existing Core and represents a novel concept that is likely to increase the research capabilities of a large number of Neuroscience Investigators as well as promote collaborations. The goal of this Core is to provide equipment for electrophysiological experiments as well as the technical capability for performing the experiments. This will allow Neuroscience investigators to carry out preliminary experiments that will test the feasibility of applying electrophysiological approaches to ongoing projects. In addition, the Core will provide a well-defined venue for Neuroscience Investigators to obtain expert advice regarding establishing electrophysiological methods in their own laboratories. This Core will be situated adjacent to the laboratories of the Director and Co-Directors (Dunlap; Blaustein & Cox). A key component of the Core that will be critical for its success is the hiring of an expert electrophysiologist. The equipment available will allow a variety of recording techniques including whole cell current and voltage clamp, single channel recording, two electrode voltage clamp, tissue slice single cell current and voltage clamp and extracellular field recording. As currently proposed, the Core would eventually have 2 rigs, the 2nd one being purchased in the 2nd year and dedicated primarily for slice electrophysiology. While the idea of having an electrophysiology core is well regarded, it is important to have realistic goals for the core. The nuances associated with slice recording that are unique to each preparation raise questions about the feasibility of incorporating slice electrophysiology into the Core. The goals of the 1st rig seem more realistic and feasible to achieve with the hiring of a well trained electrophysiologist.